Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 | P35367 | 2/20 | 0.36 |
| ▸ | SSTR5 | P35346 | 3/20 | 0.33 |
| ▸ | DRD4 | P21917 | 2/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 7/20 | 0.33 |
| ▸ | DRD2 | P14416 | 2/20 | 0.33 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.32 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.32 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.32 |
| ▸ | GPR6 | P46095 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.31 |
| ▸ | LMNA | P02545 | 2/20 | 0.31 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.31 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | MLNR | O43193 | 1/20 | 0.31 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.31 |
| ▸ | EED | O75530 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9564838 | 0.83 | SSTR5 (0.43) | HRH1SSTR5DRD4KCNH2DRD2 | |
| SCHEMBL9698779 | 0.76 | HRH1 (0.45) | HRH1SSTR5DRD4KCNH2DRD2 | |
| SCHEMBL9565053 | 0.76 | KCNH2 (0.57) | HRH1SSTR5DRD4KCNH2DRD2 | |
| SCHEMBL9565012 | 0.76 | SSTR5 (0.39) | HRH1SSTR5DRD4KCNH2DRD2 | |
| SCHEMBL9564782 | 0.76 | KCNH2 (0.45) | HRH1KCNH2NR4A2ALDH1A1LMNA | |
| SCHEMBL9564929 | 0.75 | SSTR5 (0.57) | HRH1SSTR5DRD4KCNH2DRD2 | |
| SCHEMBL9564906 | 0.74 | SSTR5 (0.39) | HRH1SSTR5DRD4KCNH2DRD2 | |
| SCHEMBL9564985 | 0.74 | SSTR5 (0.51) | HRH1SSTR5DRD4KCNH2DRD2 | |
| SCHEMBL9699544 | 0.73 | HRH1 (0.47) | HRH1SSTR5DRD4KCNH2DRD2 | |
| SCHEMBL9564954 | 0.73 | SSTR5 (0.47) | HRH1SSTR5DRD4KCNH2DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0206415-B1 | (4-PIPERIDINYLMETHYL AND -HETERO)PURINES | JANSSEN PHARMACEUTICA N.V. (BE) | 1993-01-27 | — | — | EP | disclosed |