Known targets — ChEMBL curated mechanism
ADRA2AADRA2BADRA2CADRB2AGTR1AVPR1AAVPR1BAVPR2BDKRB2CALCRCHRNA3CHRNB4ESR1ESR2GHSRGNRHRGSC1HSPA8MALT1MC1RMC4RNOS1NOS2NOS3OPRK1OXTRRAMP1RAMP2RAMP3SCN5ASSTR1SSTR2SSTR3SSTR4SSTR5dacAdacBdacCfolPftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Acetic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FKBP5 | Q13451 | 1/20 | 0.52 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 2/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | CDK2 | P24941 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | CD74 | P04233 | 1/20 | 0.33 |
| ▸ | MIF | P14174 | 1/20 | 0.33 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.33 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | SCN4A | P35499 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | BCAT2 | O15382 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Acetic Acid SCHEMBL4456446 | 0.88 | HCAR2 (0.42) | HCAR2NPC1RAB9AALOX15CDK2 | |
| Acetic Acid SCHEMBL5993449 | 0.84 | FKBP5 (0.73) | FKBP5RAB9ASMN1; SMN2KMT2ANOTUM | |
| Pyridine SCHEMBL4462835 | 0.81 | HCAR2 (0.37) | HCAR2NPC1RAB9AALOX15CDK2 | |
| Bicarbonate SCHEMBL14880924 | 0.80 | HCAR2 (0.45) | HCAR2NPC1RAB9AALOX15CDK2 | |
| Carbamic Acid SCHEMBL30801127 | 0.79 | HCAR2 (0.43) | HCAR2NPC1RAB9AALOX15CDK2 | |
| Oxalic Acid SCHEMBL27558037 | 0.79 | HCAR2 (0.43) | HCAR2NPC1RAB9AALOX15CDK2 | |
| Methyl Alcohol SCHEMBL27901542 | 0.78 | — | — | |
| Acetone SCHEMBL27901178 | 0.78 | FKBP5 (0.76) | FKBP5L3MBTL1KMT2ANOTUMNAPRT | |
| Benzene SCHEMBL27553953 | 0.78 | CYP1A2 (0.40) | FKBP5HCAR2NPC1RAB9AALOX15 | |
| SCHEMBL14767914 | 0.76 | CYP1A2 (0.43) | FKBP5HCAR2NPC1RAB9AALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1025855-C | Process and intermediates for prepation of oxophthalazinyl acetic acids and analogs thereof | PFIZER (US) | 1994-09-07 | — | — | CN | disclosed |
| US-5182391-A | Process and intermediates for the preparation of oxophthalazinyl acetic acids and analogs thereof | PFIZER INC. (US) | 1993-01-26 | — | — | US | disclosed |
| US-5171862-A | Process and indazole intermediates for the preparation of oxophthalazinyl acetic acids and analogs thereof | PFIZER INC. (US) | 1992-12-15 | — | — | US | disclosed |
| US-5075442-A | Process and intermediates for the preparation of oxophthalazinyl acetic acids and analogs thereof | PFIZER INC. (US) | 1991-12-24 | — | — | US | disclosed |
| EP-0397350-A1 | Process and intermediates for the preparation of oxophthalazinyl acetic acids and analogs thereof | PFIZER INC. (US) | 1990-11-14 | — | — | EP | disclosed |
| US-4954629-A | Process and intermediates for the preparation of oxophthalazinyl acetic acids and analogs thereof | PFIZER INC. (US) | 1990-09-04 | — | — | US | disclosed |