Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KAT2B | Q92831 | 2/20 | 0.58 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.53 |
| ▸ | MAPT | P10636 | 5/20 | 0.49 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 2/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | HTT | P42858 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18583908 | 0.92 | KAT2B (0.53) | KAT2BL3MBTL1MAPTTDP1TSHR | |
| SCHEMBL17445130 | 0.87 | KAT2B (0.49) | KAT2BL3MBTL1MAPTTDP1TSHR | |
| SCHEMBL14754095 | 0.83 | KAT2B (0.59) | KAT2BL3MBTL1MAPTPTGER4TDP1 | |
| SCHEMBL2184870 | 0.82 | PTGER4 (0.56) | L3MBTL1MAPTPTGER4MAPK1ALDH1A1 | |
| SCHEMBL28183335 | 0.82 | ALDH1A1 (0.57) | L3MBTL1MAPTPTGER4TDP1CYP3A4 | |
| SCHEMBL3369999 | 0.82 | KMT2A (0.69) | L3MBTL1MAPTTDP1ALDH1A1HTT | |
| SCHEMBL15828723 | 0.82 | KMT2A (0.53) | L3MBTL1MAPTPTGER4NPC1MAPK1 | |
| SCHEMBL7820001 | 0.82 | MEN1 (0.54) | L3MBTL1MAPTTDP1NPC1MAPK1 | |
| SCHEMBL4382288 | 0.82 | KAT2B (0.53) | KAT2BL3MBTL1MAPTTSHRCYP3A4 | |
| SCHEMBL11909344 | 0.81 | KAT2B (0.46) | KAT2BL3MBTL1MAPTTDP1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3318557-A2 | QUINOLONE COMPOUND | Otsuka Pharmaceutical Co., Ltd. (JP) | 2018-05-09 | — | — | EP | disclosed |
| US-9139576-B2 | Aminomethyl biaryl benzotriazole derivatives | MERCK SHARP & DOHME CORP. (US) | 2015-09-22 | — | — | US | disclosed |
| US-8975286-B2 | Ether benzotriazole derivatives | MERCK SHARP & DOHME CORP. (US) | 2015-03-10 | — | — | US | disclosed |
| US-8785482-B2 | Cyclohexene benzotriazole derivatives | MERCK SHARP & DOHME CORP. (US) | 2014-07-22 | — | — | US | disclosed |
| US-8785481-B2 | Ether benzotriazole derivatives | MERCK SHARP & DOHME CORP. (US) | 2014-07-22 | — | — | US | disclosed |
| US-8772276-B2 | Alkyne benzotriazole derivatives | MERCK SHARP & DOHME CORP. (US) | 2014-07-08 | — | — | US | disclosed |
| US-20140088112-A1 | ALKYNE BENZOTRIAZOLE DERIVATIVES | MERCK SHARP & DOHME LLC | 2014-03-27 | — | — | US | disclosed |
| US-20140088151-A1 | ALHYDROXYMETHYL BIARYL BENZOTRIAZOLE DERIVATIVES | MERCK SHARP & DOHME CORP. | 2014-03-27 | — | — | US | disclosed |
| US-20140088150-A1 | CYCLOHEXENE BENZOTRIAZOLE DERIVATIVES | MERCK SHARP & DOHME LLC | 2014-03-27 | — | — | US | disclosed |
| US-20140066443-A1 | AMINOMETHYL BIARYL BENZOTRIAZOLE DERIVATIVES | MERCK SHARP & DOHME LLC | 2014-03-06 | — | — | US | disclosed |
| US-20120149677-A1 | ETHER BENZOTRIAZOLE DERIVATIVES | MERCK SHARP & DOHME LLC | 2012-06-14 | — | — | US | disclosed |
| US-20120135977-A1 | ETHER BENZOTRIAZOLE DERIVATIVES | MERCK SHARP & DOHME LLC | 2012-05-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140088150-A1 | CYCLOHEXENE BENZOTRIAZOLE DERIVATIVES | GRM2, GRIA2, GRIK2 | KAT2B 1649/4885L3MBTL1 4022/4885MAPT 535/4885 |
| US-20120149677-A1 | ETHER BENZOTRIAZOLE DERIVATIVES | GRM2, GRIA2, GRIK2 | KAT2B 1263/4885L3MBTL1 2893/4885MAPT 362/4885 |
| US-20120135977-A1 | ETHER BENZOTRIAZOLE DERIVATIVES | GRM2, GRIA2, GRIK2 | KAT2B 1263/4885L3MBTL1 2893/4885MAPT 362/4885 |
| US-20140066443-A1 | AMINOMETHYL BIARYL BENZOTRIAZOLE DERIVATIVES | GRM2, GRM3, GRIN2C | KAT2B 1212/4885L3MBTL1 3281/4885MAPT 462/4885 |
| US-20140088112-A1 | ALKYNE BENZOTRIAZOLE DERIVATIVES | GRM2, GRIA2, GRM3 | KAT2B 1387/4885L3MBTL1 3093/4885MAPT 536/4885 |
| US-20140088151-A1 | ALHYDROXYMETHYL BIARYL BENZOTRIAZOLE DERIVATIVES | GRM2, GRIA2, GRM3 | KAT2B 1213/4885L3MBTL1 3393/4885MAPT 693/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.