Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KAT2B | Q92831 | 3/20 | 0.53 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | HTT | P42858 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | GRK6 | P43250 | 2/20 | 0.44 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.43 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14261252 | 0.86 | NPC1 (0.44) | KAT2BMAPTHTTALDH1A1SMN1; SMN2 | |
| SCHEMBL1528590 | 0.84 | MAPT (0.47) | MAPTHTTALDH1A1SMN1; SMN2ALOX12 | |
| SCHEMBL8885926 | 0.84 | ALDH1A1 (0.52) | MAPTHTTALDH1A1SMN1; SMN2TSHR | |
| SCHEMBL15099939 | 0.82 | KAT2B (0.46) | KAT2BMAPTALDH1A1GRK6PRKCQ | |
| SCHEMBL9604230 | 0.82 | KAT2B (0.58) | KAT2BMAPTHTTALDH1A1SMN1; SMN2 | |
| SCHEMBL1528454 | 0.80 | HPGD (0.56) | MAPTHTTALDH1A1L3MBTL1PKM | |
| SCHEMBL23997424 | 0.80 | ALDH1A1 (0.51) | KAT2BMAPTHTTALDH1A1SMN1; SMN2 | |
| SCHEMBL26161783 | 0.80 | ALOX12 (0.57) | KAT2BMAPTHTTALDH1A1CYP3A4 | |
| SCHEMBL5955184 | 0.80 | MAPT (0.57) | MAPTHTTALDH1A1SMN1; SMN2CYP3A4 | |
| SCHEMBL5956104 | 0.79 | MMP13 (0.47) | MAPTHTTALDH1A1SMN1; SMN2L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090298811-A1 | BENZIMIDAZOLONE DERIVATIVES | PFIZER INC | 2009-12-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090298811-A1 | BENZIMIDAZOLONE DERIVATIVES | TRPV1, CNR1, CNR2 | KAT2B 741/4885MAPT 1466/4885HTT 2456/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.