Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IRAK4 | Q9NWZ3 | 6/20 | 0.52 |
| ▸ | NPC1 | O15118 | 2/20 | 0.52 |
| ▸ | RAB9A | P51151 | 2/20 | 0.52 |
| ▸ | TLR7 | Q9NYK1 | 8/20 | 0.48 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.45 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2141469 | 0.85 | RAB9A (0.46) | IRAK4NPC1RAB9ATLR7CHEK1 | |
| SCHEMBL2140404 | 0.85 | IRAK4 (0.55) | IRAK4NPC1RAB9ATLR7CHEK1 | |
| SCHEMBL18427815 | 0.85 | TDP1 (0.65) | IRAK4NPC1RAB9ATLR7CHEK1 | |
| SCHEMBL2138888 | 0.83 | IRAK4 (0.74) | IRAK4NPC1RAB9ATLR7CHEK1 | |
| SCHEMBL12658132 | 0.83 | LMNA (0.48) | IRAK4NPC1RAB9ATLR7CHEK1 | |
| SCHEMBL2138509 | 0.83 | CHEK1 (0.59) | IRAK4NPC1RAB9ATLR7CHEK1 | |
| SCHEMBL2140234 | 0.80 | IRAK4 (0.56) | IRAK4NPC1RAB9ATLR7CHEK1 | |
| SCHEMBL2919406 | 0.79 | IRAK4 (0.52) | IRAK4NPC1RAB9ATLR7CHEK1 | |
| SCHEMBL2771222 | 0.77 | RAB9A (0.60) | IRAK4NPC1RAB9ACHEK1LMNA | |
| SCHEMBL1829073 | 0.77 | CHEK1 (0.67) | NPC1RAB9ACHEK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2231652-B1 | NOVEL 2-HETARYL THIAZOLE-4-CARBOXAMIDE DERIVATIVES, PRODUCTION THEREOF, AND USE THEREOF AS A MEDICAMENT | Bayer Pharma AG (DE) | 2012-05-30 | — | — | EP | disclosed |
| WO-2009074246-A1 | NOVEL 2-HETARYL THIAZOLE-4-CARBOXAMIDE DERIVATIVES, PRODUCTION THEREOF, AND USE THEREOF AS A MEDICAMENT | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2009-06-18 | — | — | WO | disclosed |
| EP-2070924-A1 | New 2 hetarylthiazol-4-carboxylic acid derivatives, their manufacture and use as medicine | Bayer Schering Pharma Aktiengesellschaft (DE) | 2009-06-17 | — | — | EP | disclosed |