Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.40 |
| ▸ | RAB9A | P51151 | 4/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | SCD | O00767 | 1/20 | 0.38 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.37 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9837932 | 0.92 | NPC1 (0.42) | NPC1RAB9AHPGDSMN1; SMN2SCD | |
| SCHEMBL9605133 | 0.88 | RAB9A (0.38) | NPC1RAB9AHPGDSMN1; SMN2MEN1 | |
| SCHEMBL9602628 | 0.86 | RAB9A (0.39) | NPC1RAB9AHPGDSMN1; SMN2MEN1 | |
| SCHEMBL9605284 | 0.83 | RAB9A (0.39) | NPC1RAB9AHPGDSMN1; SMN2MEN1 | |
| SCHEMBL9837751 | 0.83 | NPC1 (0.41) | NPC1RAB9AHPGDSMN1; SMN2MEN1 | |
| SCHEMBL9838903 | 0.82 | RAB9A (0.40) | NPC1RAB9AHPGDSMN1; SMN2MEN1 | |
| SCHEMBL10667122 | 0.81 | KDM4E (0.40) | MEN1KMT2A | |
| SCHEMBL10518993 | 0.81 | NPC1 (0.40) | NPC1RAB9AHPGDSMN1; SMN2LMNA | |
| SCHEMBL9839261 | 0.81 | NPC1 (0.40) | NPC1RAB9AHPGDSMN1; SMN2MEN1 | |
| SCHEMBL11620300 | 0.81 | HTT (0.44) | NPC1RAB9AHPGDSMN1; SMN2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0214004-B1 | 4-OH-QUINOLINE-CARBOXYLIC-ACID DERIVATIVES SUBSTITUTED IN POSITION 2 BY A DIHYDROXY-SUBSTITUTED GROUP, POSSIBLY ETHERIFIED OR ESTERIFIED, PROCESS AND INTERMEDIATES FOR THEIR PREPARATION, THEIR USE AS MEDICAMENTS AND COMPOSITIONS CONTAINING THEM | ROUSSEL-UCLAF (FR) | 1993-03-31 | — | — | EP | disclosed |
| US-4988708-A | 3-Carbamoyl-4-hydroxy-2-carboxylmethyl quinoline analgesics, antiinflammatory agents | ROUSSEL UCLAF (FR) | 1991-01-29 | — | — | US | disclosed |
| US-4845105-A | 4-OH-quinoline carboxylic acid amides having analgesic and anti-inflammatory activity | ROUSSEL UCLAF (FR) | 1989-07-04 | — | — | US | disclosed |