Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 2/20 | 0.65 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.65 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.65 |
| ▸ | RELA | Q04206 | 2/20 | 0.62 |
| ▸ | APP | P05067 | 3/20 | 0.61 |
| ▸ | TTR | P02766 | 2/20 | 0.56 |
| ▸ | MMP1 | P03956 | 1/20 | 0.54 |
| ▸ | MMP2 | P08253 | 1/20 | 0.54 |
| ▸ | MMP9 | P14780 | 1/20 | 0.54 |
| ▸ | NQO2 | P16083 | 2/20 | 0.53 |
| ▸ | LCK | P06239 | 1/20 | 0.53 |
| ▸ | TP53 | P04637 | 3/20 | 0.52 |
| ▸ | CA12 | O43570 | 2/20 | 0.52 |
| ▸ | CA1 | P00915 | 2/20 | 0.52 |
| ▸ | CA2 | P00918 | 2/20 | 0.52 |
| ▸ | CA3 | P07451 | 2/20 | 0.52 |
| ▸ | CA4 | P22748 | 2/20 | 0.52 |
| ▸ | CA6 | P23280 | 2/20 | 0.52 |
| ▸ | CA5A | P35218 | 2/20 | 0.52 |
| ▸ | CA7 | P43166 | 2/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29673932 | 0.89 | RELA (0.74) | ALOX5PTGS1PTGS2RELATP53 | |
| SCHEMBL1179749 | 0.89 | RELA (0.74) | ALOX5PTGS1PTGS2RELATP53 | |
| SCHEMBL1179750 | 0.89 | RELA (0.74) | ALOX5PTGS1PTGS2RELATP53 | |
| SCHEMBL15999198 | 0.86 | LCK (0.67) | ALOX5PTGS1PTGS2RELAMMP1 | |
| SCHEMBL11981433 | 0.86 | LCK (0.67) | ALOX5PTGS1PTGS2RELAMMP1 | |
| SCHEMBL16105651 | 0.85 | RELA (0.69) | ALOX5PTGS1PTGS2RELATP53 | |
| SCHEMBL16105706 | 0.85 | RELA (0.69) | ALOX5PTGS1PTGS2RELATP53 | |
| SCHEMBL16105653 | 0.85 | RELA (0.69) | ALOX5PTGS1PTGS2RELATP53 | |
| SCHEMBL1931278 | 0.85 | APP (0.73) | ALOX5PTGS1PTGS2RELAAPP | |
| SCHEMBL1795132 | 0.85 | PTGS1 (0.69) | ALOX5PTGS1PTGS2RELATP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120135091-A1 | METHODS AND COMPOSITIONS FOR ENHANCING LIFESPAN INVOLVING SIRTUIN-MODULATING COMPOUNDS AND CHALCOGENIDES | US ARMY, SECRETARY OF THE ARMY | 2012-05-31 | — | — | US | disclosed |
| US-20070014833-A1 | Treatment of eye disorders with sirtuin modulators | SIRTRIS PHARMACEUTICALS, INC. (US) | 2007-01-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070014833-A1 | Treatment of eye disorders with sirtuin modulators | SIRT1, SIRT2, SIRT3 | ALOX5 3996/4885PTGS1 1853/4885PTGS2 2158/4885 |
| US-20120135091-A1 | METHODS AND COMPOSITIONS FOR ENHANCING LIFESPAN INVOLVING SIRTUIN-MODULATING COMPOUNDS AND CHALCOGENIDES | HSF1, SIRT1, SIRT2 | ALOX5 1792/4885PTGS1 168/4885PTGS2 192/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.