Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 2/20 | 0.54 |
| ▸ | HTT | P42858 | 2/20 | 0.54 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.43 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.43 |
| ▸ | HPGD | P15428 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.43 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.39 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.39 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.39 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.39 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL540942 | 0.77 | MAPK1 (0.68) | MAPK1HTTTSHRALDH1A1HPGD | |
| SCHEMBL22507416 | 0.75 | MAPK1 (0.74) | MAPK1HTTTSHRALDH1A1KDM4E | |
| SCHEMBL10041256 | 0.75 | MAPK1 (0.79) | MAPK1HTTTSHRALDH1A1KDM4E | |
| SCHEMBL13030954 | 0.75 | HTT (0.79) | MAPK1HTTTSHRALDH1A1KDM4E | |
| SCHEMBL22507417 | 0.75 | MAPK1 (0.68) | MAPK1HTTTSHRALDH1A1HPGD | |
| SCHEMBL20881962 | 0.75 | TSHR (0.64) | MAPK1HTTTSHRALDH1A1KDM4E | |
| SCHEMBL17694823 | 0.74 | MAPK1 (0.67) | MAPK1HTTTSHRALDH1A1HPGD | |
| SCHEMBL22507480 | 0.74 | HTT (0.67) | MAPK1HTTTSHRALDH1A1KDM4E | |
| SCHEMBL16122597 | 0.74 | MAPK1 (0.50) | MAPK1HTTTSHRALDH1A1HPGD | |
| SCHEMBL23245562 | 0.74 | TRPV4 (0.47) | MAPK1PDE4BPDE4DALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8835445-B2 | Dihydrofolate reductase inhibitors | TRIUS THERAPEUTICS, INC. (US) | 2014-09-16 | — | — | US | disclosed |
| US-20120136014-A1 | DIHYDROFOLATE REDUCTASE INHIBITORS | TRIUS THERAPEUTICS, INC. (US) | 2012-05-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120136014-A1 | DIHYDROFOLATE REDUCTASE INHIBITORS | DHFR, DPYD, DHODH | MAPK1 1582/4885HTT 2141/4885TSHR 2228/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.