Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 5/20 | 0.40 |
| ▸ | NPC1 | O15118 | 4/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9605409 | 0.91 | HTT (0.42) | HTTLMNATSHRRAB9ANPC1 | |
| SCHEMBL10660942 | 0.89 | HTT (0.44) | HTTLMNATSHRRAB9ANPC1 | |
| SCHEMBL10941363 | 0.89 | LMNA (0.43) | HTTLMNATSHRRAB9ANPC1 | |
| SCHEMBL9605284 | 0.86 | RAB9A (0.39) | HTTLMNATSHRRAB9ANPC1 | |
| SCHEMBL11620300 | 0.86 | HTT (0.44) | HTTLMNATSHRRAB9ANPC1 | |
| SCHEMBL10942295 | 0.86 | HTT (0.44) | HTTLMNATSHRRAB9ANPC1 | |
| SCHEMBL10659235 | 0.85 | HTT (0.43) | HTTLMNATSHRRAB9ANPC1 | |
| SCHEMBL9601722 | 0.84 | SCN9A (0.45) | HTTLMNATSHRRAB9ANPC1 | |
| SCHEMBL9837900 | 0.84 | HSPA5 (0.43) | HTTLMNATSHRRAB9ANPC1 | |
| SCHEMBL10744027 | 0.84 | HTT (0.42) | HTTLMNATSHRRAB9ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0214004-B1 | 4-OH-QUINOLINE-CARBOXYLIC-ACID DERIVATIVES SUBSTITUTED IN POSITION 2 BY A DIHYDROXY-SUBSTITUTED GROUP, POSSIBLY ETHERIFIED OR ESTERIFIED, PROCESS AND INTERMEDIATES FOR THEIR PREPARATION, THEIR USE AS MEDICAMENTS AND COMPOSITIONS CONTAINING THEM | ROUSSEL-UCLAF (FR) | 1993-03-31 | — | — | EP | disclosed |
| US-4988708-A | 3-Carbamoyl-4-hydroxy-2-carboxylmethyl quinoline analgesics, antiinflammatory agents | ROUSSEL UCLAF (FR) | 1991-01-29 | — | — | US | disclosed |
| US-4845105-A | 4-OH-quinoline carboxylic acid amides having analgesic and anti-inflammatory activity | ROUSSEL UCLAF (FR) | 1989-07-04 | — | — | US | disclosed |
| EP-0214004-A2 | 4-OH-quinoline-carboxylic-acid derivatives substituted in position 2 by a dihydroxy-substituted group, possibly etherified or esterified, process and intermediates for their preparation, their use as medicaments and compositions containing them | ROUSSEL-UCLAF (FR) | 1987-03-11 | — | — | EP | disclosed |