⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3078982 | 0.69 | LMNA (0.40) | — | |
| SCHEMBL708170 | 0.69 | — | — | |
| SCHEMBL13239618 | 0.67 | — | — | |
| SCHEMBL379201 | 0.67 | — | — | |
| SCHEMBL7539852 | 0.64 | — | — | |
| SCHEMBL838161 | 0.64 | — | — | |
| SCHEMBL742517 | 0.64 | — | — | |
| SCHEMBL3590719 | 0.64 | — | — | |
| SCHEMBL15295104 | 0.64 | — | — | |
| SCHEMBL3419745 | 0.64 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013120871-A1 | PROCESS FOR THE PREPARATION OF A VIRAL PROTEASE INHIBITOR AND ITS INTERMEDIATES | DIPHARMA FRANCIS S.R.L. (IT) | 2013-08-22 | — | — | WO | disclosed |
| EP-2049478-B1 | SUBSTITUTED N-PHENYLMETHYL -5-OXO-PROLINE-2-AMIDES AS P2X7-RECEPTOR ANTAGONISTS AND THEIR METHODS OF USE | GLAXO GROUP LTD (GB) | 2012-05-30 | — | — | EP | disclosed |
| WO-2008003697-A1 | SUBSTITUTED N-PHENYLMETHYL -5-OXO-PROLINE-2-AMIDES AS P2X7-RECEPTOR ANTAGONISTS AND THEIR METHODS OF USE | GLAXO GROUP LIMITED (GB) | 2008-01-10 | — | — | WO | disclosed |