Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 17/20 | 0.77 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2582032 | 0.87 | P2RX7 (1.00) | P2RX7 | |
| SCHEMBL2582031 | 0.87 | P2RX7 (1.00) | P2RX7 | |
| SCHEMBL2580781 | 0.85 | P2RX7 (1.00) | P2RX7 | |
| SCHEMBL2580782 | 0.85 | P2RX7 (1.00) | P2RX7 | |
| SCHEMBL2581958 | 0.83 | P2RX7 (1.00) | P2RX7 | |
| SCHEMBL2581960 | 0.83 | P2RX7 (1.00) | P2RX7 | |
| SCHEMBL9606576 | 0.80 | P2RX7 (0.78) | P2RX7 | |
| SCHEMBL2575686 | 0.79 | P2RX7 (1.00) | P2RX7 | |
| SCHEMBL2575688 | 0.79 | P2RX7 (1.00) | P2RX7 | |
| SCHEMBL2575872 | 0.78 | P2RX7 (1.00) | P2RX7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2049478-B1 | SUBSTITUTED N-PHENYLMETHYL -5-OXO-PROLINE-2-AMIDES AS P2X7-RECEPTOR ANTAGONISTS AND THEIR METHODS OF USE | GLAXO GROUP LTD (GB) | 2012-05-30 | — | — | EP | disclosed |