Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.49 |
| ▸ | CA12 | O43570 | 1/20 | 0.49 |
| ▸ | CA1 | P00915 | 1/20 | 0.49 |
| ▸ | CA2 | P00918 | 1/20 | 0.49 |
| ▸ | CA7 | P43166 | 1/20 | 0.49 |
| ▸ | CA9 | Q16790 | 1/20 | 0.49 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 6/20 | 0.47 |
| ▸ | MEN1 | O00255 | 5/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.47 |
| ▸ | GAA | P10253 | 5/20 | 0.47 |
| ▸ | HPGD | P15428 | 4/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2253345 | 0.94 | CA12 (0.55) | ALDH1A1KDM4ESMN1; SMN2CA12CA1 | |
| SCHEMBL10058490 | 0.88 | CA12 (0.60) | ALDH1A1KDM4ESMN1; SMN2CA12CA1 | |
| SCHEMBL3564213 | 0.88 | KDM4E (0.50) | ALDH1A1KDM4ESMN1; SMN2CA12CA1 | |
| SCHEMBL1590061 | 0.86 | ALDH1A1 (0.55) | ALDH1A1KDM4ECA12CA1CA2 | |
| SCHEMBL1590733 | 0.84 | KMT2A (0.50) | ALDH1A1KDM4ESMN1; SMN2CA12CA1 | |
| SCHEMBL3560450 | 0.84 | CA12 (0.45) | ALDH1A1KDM4ESMN1; SMN2CA12CA1 | |
| SCHEMBL9606731 | 0.83 | KDM4E (0.43) | ALDH1A1KDM4ESMN1; SMN2TSHRMAPT | |
| SCHEMBL2295378 | 0.83 | CA12 (0.50) | ALDH1A1KDM4ESMN1; SMN2CA12CA1 | |
| SCHEMBL9606721 | 0.82 | ALDH1A1 (0.44) | ALDH1A1KDM4ESMN1; SMN2CA12CA1 | |
| SCHEMBL3571825 | 0.82 | KDM4E (0.52) | ALDH1A1KDM4ESMN1; SMN2CA12CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2457897-A1 | BENZO (F) ISOINDOL-2-YLPHENYL ACETIC ACID DERIVATIVES AS EP4 RECEPTOR AGONISTS | Glaxo Group Limited (GB) | 2012-05-30 | — | — | EP | disclosed |