Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 1/20 | 0.60 |
| ▸ | CA1 | P00915 | 1/20 | 0.60 |
| ▸ | CA2 | P00918 | 1/20 | 0.60 |
| ▸ | CA7 | P43166 | 1/20 | 0.60 |
| ▸ | CA9 | Q16790 | 1/20 | 0.60 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.60 |
| ▸ | TSHR | P16473 | 1/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.57 |
| ▸ | GAA | P10253 | 4/20 | 0.51 |
| ▸ | MAPT | P10636 | 4/20 | 0.51 |
| ▸ | NPC1 | O15118 | 2/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | HPGD | P15428 | 2/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 3/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30881958 | 0.92 | CA12 (0.56) | CA12CA1CA2CA7CA9 | |
| SCHEMBL9606773 | 0.91 | ALDH1A1 (0.58) | CA12CA1CA2CA7CA9 | |
| SCHEMBL9606730 | 0.88 | ALDH1A1 (0.49) | CA12CA1CA2CA7CA9 | |
| SCHEMBL1590707 | 0.82 | ALDH1A1 (0.65) | CA12CA1CA2CA7CA9 | |
| SCHEMBL28966737 | 0.81 | GAA (0.50) | CA12CA1CA2CA7CA9 | |
| SCHEMBL28966727 | 0.81 | ALDH1A1 (0.46) | CA12CA1CA2CA7CA9 | |
| SCHEMBL9397467 | 0.80 | ALDH1A1 (0.58) | CA12CA1CA2CA7CA9 | |
| SCHEMBL31442541 | 0.80 | SMN1; SMN2 (0.71) | ALDH1A1KDM4ESMN1; SMN2GAAMAPT | |
| SCHEMBL10256511 | 0.80 | SMN1; SMN2 (0.71) | ALDH1A1KDM4ESMN1; SMN2GAAMAPT | |
| SCHEMBL5835576 | 0.79 | CA12 (0.55) | CA12CA1CA2CA7CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8207213-B2 | Benzoisoindole derivatives for the treatment of pain | GLAXO GROUP LIMITED (GB) | 2012-06-26 | — | — | US | disclosed |
| US-8026270-B2 | Benzo [F] isoindoles as EP4 receptor agonists | GLAXO GROUP LIMITED (GB) | 2011-09-27 | — | — | US | disclosed |
| US-20110092561-A1 | BENZOISOINDOLE DERIVATIVES FOR THE TREATMENT OF PAIN | GLAXO GROUP LIMITED (GB) | 2011-04-21 | — | — | US | disclosed |
| US-20100076048-A1 | Isoindol Derivatives As EP4 Receptor Agonists | GLAXO GROUP LIMITED (GB) | 2010-03-25 | — | — | US | disclosed |
| US-20100069457-A1 | Naphthalene Derivatives Used As EP4 Receptor Agonists | GLAXO GROUP LIMITED (GB) | 2010-03-18 | — | — | US | disclosed |
| US-20090318523-A1 | BENZOISOINDOLE DERIVATIVES AND THEIR USE AS EP4 RECEPTOR AGONISTS | GLAXO GROUP LIMITED | 2009-12-24 | — | — | US | disclosed |
| US-20090312388-A1 | Benzo [F] Isoindoles As EP4 Receptor Agonists | GLAXO GROUP LIMITED | 2009-12-17 | — | — | US | disclosed |
| US-7173047-B2 | Benzo (f) insoindol derivatives and their use as ep4 receptor ligands | GLAXO GROUP LIMITED (GB) | 2007-02-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110092561-A1 | BENZOISOINDOLE DERIVATIVES FOR THE TREATMENT OF PAIN | OPRK1, OPRD1, OPRL1 | CA12 4283/4885CA1 4094/4885CA2 2811/4885 |
| US-20090312388-A1 | Benzo [F] Isoindoles As EP4 Receptor Agonists | PTGER4, GPR4, PTGER1 | CA12 4795/4885CA1 4822/4885CA2 3710/4885 |
| US-20090318523-A1 | BENZOISOINDOLE DERIVATIVES AND THEIR USE AS EP4 RECEPTOR AGONISTS | PTGER4, PTGER3, HTR4 | CA12 4516/4885CA1 4599/4885CA2 2637/4885 |
| US-20100069457-A1 | Naphthalene Derivatives Used As EP4 Receptor Agonists | PTGER4, PTGER1, PTGER3 | CA12 4613/4885CA1 4786/4885CA2 3918/4885 |
| US-20100076048-A1 | Isoindol Derivatives As EP4 Receptor Agonists | PTGER4, PTGER1, PTGER3 | CA12 4874/4885CA1 4873/4885CA2 4565/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.