Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 1/20 | 0.47 |
| ▸ | KMO | O15229 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.42 |
| ▸ | ALPL | P05186 | 3/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | HPGDS | O60760 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | MAOB | P27338 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.39 |
| ▸ | FEN1 | P39748 | 1/20 | 0.39 |
| ▸ | KDM4A | O75164 | 1/20 | 0.38 |
| ▸ | KDM5A | P29375 | 1/20 | 0.38 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.38 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4388622 | 0.82 | P4HA1 (0.58) | DHODHKMONPC1RXFP1ALPL | |
| SCHEMBL3501871 | 0.75 | DHODH (0.44) | DHODHKMONPC1RXFP1ALPL | |
| SCHEMBL30540118 | 0.75 | KMO (0.47) | DHODHKMONPC1ALPLRAB9A | |
| SCHEMBL19248543 | 0.75 | KMO (0.47) | DHODHKMONPC1ALPLRAB9A | |
| SCHEMBL15060602 | 0.75 | GRM2 (0.47) | DHODHKMONPC1ALPLRAB9A | |
| SCHEMBL3500766 | 0.74 | NPC1 (0.58) | NPC1RXFP1MAPTRAB9AHPGDS | |
| SCHEMBL5934119 | 0.73 | DHODH (0.51) | DHODHNPC1MAPTRAB9AMEN1 | |
| SCHEMBL8515855 | 0.72 | SMN1; SMN2 (0.55) | DHODHKMONPC1MAPTRAB9A | |
| SCHEMBL23319259 | 0.72 | KMO (0.46) | DHODHKMOALPLALOX5APFEN1 | |
| SCHEMBL15574132 | 0.72 | DHODH (0.55) | DHODHKMOALPLALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012069856-A1 | ANTIMALARIAL COMPOUNDS | LIVERPOOL SCHOOL OF TROPICAL MEDICINE (GB) | 2012-05-31 | — | — | WO | disclosed |