Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F9 | P00740 | 8/20 | 0.65 |
| ▸ | F10 | P00742 | 7/20 | 0.65 |
| ▸ | F11 | P03951 | 5/20 | 0.65 |
| ▸ | F7 | P08709 | 4/20 | 0.65 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | KDR | P35968 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | GBA1 | P04062 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | F2 | P00734 | 5/20 | 0.36 |
| ▸ | PLG | P00747 | 4/20 | 0.36 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.36 |
| ▸ | PRMT1 | Q99873 | 2/20 | 0.36 |
| ▸ | PLAU | P00749 | 4/20 | 0.36 |
| ▸ | PLAT | P00750 | 4/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | NQO2 | P16083 | 1/20 | 0.36 |
| ▸ | KLK1 | P06870 | 1/20 | 0.36 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.36 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6919971 | 0.89 | F9 (0.48) | F9F10F11F7CYP2C9 | |
| SCHEMBL9607621 | 0.83 | F9 (0.64) | F9F10F11F7CYP2C9 | |
| SCHEMBL1233111 | 0.82 | F9 (0.65) | F9F10F11F7CYP2C9 | |
| SCHEMBL9607754 | 0.81 | F9 (0.41) | F9F10F11F7CYP2C9 | |
| SCHEMBL1232626 | 0.81 | F9 (0.48) | F9F10F11F7CYP2C9 | |
| SCHEMBL1232151 | 0.80 | F9 (0.62) | F9F10F11F7CYP2C9 | |
| SCHEMBL1232149 | 0.79 | F9 (1.00) | F9F10F11F7CYP2C9 | |
| SCHEMBL6919197 | 0.78 | F9 (0.59) | F9F10F11F7CYP2C9 | |
| SCHEMBL1231149 | 0.70 | F9 (0.65) | F9F10F11F7KDR | |
| SCHEMBL9607763 | 0.70 | MEN1 (0.52) | F9F10F11F7CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2462123-B1 | 4,5,6-TRISUBSTITUTED PYRIMIDINE DERIVATIVES AS FACTOR IXA INHIBITORS | MERCK SHARP & DOHME (US) | 2013-10-02 | — | — | EP | disclosed |
| US-20120136016-A1 | 4, 5, 6-TRISUBSTITUTED PYRIMIDINE DERIVATIVES AS FACTOR IXA INHIBITORS | MERCK SHARP & DOHME LLC | 2012-05-31 | — | — | US | disclosed |
| US-20120136016-A1 | 4, 5, 6-TRISUBSTITUTED PYRIMIDINE DERIVATIVES AS FACTOR IXA INHIBITORS | MERCK SHARP & DOHME LLC | 2012-05-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120136016-A1 | 4, 5, 6-TRISUBSTITUTED PYRIMIDINE DERIVATIVES AS FACTOR IXA INHIBITORS | F9, F8, F12 | F9 1/4885F10 9/4885F11 5/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.