Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | APEX1 | P27695 | 1/20 | 0.34 |
| ▸ | KDR | P35968 | 2/20 | 0.34 |
| ▸ | LCK | P06239 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 2/20 | 0.33 |
| ▸ | EGFR | P00533 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6919277 | 0.81 | ALDH1A1 (0.46) | LMNAALDH1A1SMN1; SMN2RAB9ACYP2C9 | |
| SCHEMBL6918371 | 0.77 | MAPK1 (0.43) | LMNAALDH1A1SMN1; SMN2RAB9ACYP2C9 | |
| SCHEMBL9607636 | 0.74 | TTBK1 (0.45) | LMNASMN1; SMN2RAB9AKDREGFR | |
| SCHEMBL9044468 | 0.72 | ALDH1A1 (0.39) | LMNAALDH1A1SMN1; SMN2RAB9ALCK | |
| SCHEMBL1748605 | 0.71 | ALDH1A1 (0.56) | LMNAALDH1A1SMN1; SMN2RAB9ACYP2C9 | |
| SCHEMBL15155123 | 0.70 | GALR3 (0.51) | LMNAALDH1A1SMN1; SMN2RAB9ACYP2C9 | |
| SCHEMBL8419304 | 0.70 | ENPP1 (0.45) | LMNAALDH1A1SMN1; SMN2RAB9ACYP2C9 | |
| SCHEMBL1232178 | 0.68 | TRPA1 (0.51) | LMNAALDH1A1SMN1; SMN2RAB9ACYP2C9 | |
| SCHEMBL29072754 | 0.68 | ALDH1A1 (0.35) | LMNAALDH1A1SMN1; SMN2MAPTKDM4E | |
| SCHEMBL30117115 | 0.68 | ALDH1A1 (0.35) | LMNAALDH1A1SMN1; SMN2MAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120136016-A1 | 4, 5, 6-TRISUBSTITUTED PYRIMIDINE DERIVATIVES AS FACTOR IXA INHIBITORS | MERCK SHARP & DOHME LLC | 2012-05-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120136016-A1 | 4, 5, 6-TRISUBSTITUTED PYRIMIDINE DERIVATIVES AS FACTOR IXA INHIBITORS | F9, F8, F12 | LMNA 1461/4885ALDH1A1 569/4885SMN1; SMN2 3437/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.