Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | HSD11B1 | P28845 | 4/20 | 0.43 |
| ▸ | HSD11B2 | P80365 | 4/20 | 0.43 |
| ▸ | BACE1 | P56817 | 3/20 | 0.36 |
| ▸ | ESR1 | P03372 | 3/20 | 0.36 |
| ▸ | ESR2 | Q92731 | 3/20 | 0.36 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | HTR2B | P41595 | 1/20 | 0.33 |
| ▸ | RBP1 | P09455 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9607812 | 0.98 | HSD11B1 (0.41) | ALDH1A1L3MBTL1HSD11B1HSD11B2BACE1 | |
| SCHEMBL978581 | 0.85 | BACE1 (0.50) | ALDH1A1L3MBTL1HSD11B1HSD11B2BACE1 | |
| SCHEMBL9607808 | 0.84 | CSNK1A1 (0.42) | ALDH1A1L3MBTL1HSD11B1HSD11B2MEN1 | |
| SCHEMBL9607811 | 0.84 | BACE1 (0.54) | ALDH1A1L3MBTL1BACE1 | |
| SCHEMBL1023748 | 0.83 | BACE1 (0.51) | ALDH1A1L3MBTL1HSD11B1HSD11B2BACE1 | |
| SCHEMBL9607809 | 0.83 | CSNK1A1 (0.43) | ALDH1A1L3MBTL1HSD11B1HSD11B2ALOX5AP | |
| SCHEMBL9607813 | 0.82 | BACE1 (0.54) | ALDH1A1L3MBTL1BACE1 | |
| SCHEMBL1025471 | 0.80 | BACE1 (0.48) | HSD11B1HSD11B2BACE1 | |
| SCHEMBL976986 | 0.78 | BACE1 (0.46) | ALDH1A1L3MBTL1HSD11B1HSD11B2BACE1 | |
| SCHEMBL9607819 | 0.78 | BACE1 (0.49) | ALDH1A1BACE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2451807-B1 | CYCLIC TRIAZO SODIUM CHANNEL BLOCKERS | UNIV GREENWICH (GB) | 2015-09-02 | — | — | EP | disclosed |
| US-8748600-B2 | Cyclic triazo sodium channel blockers | UNIVERSITY OF GREENWICH (GB) | 2014-06-10 | — | — | US | disclosed |
| US-8748600-B2 | Cyclic triazo sodium channel blockers | UNIVERSITY OF GREENWICH (GB) | 2014-06-10 | — | — | US | disclosed |
| US-20120135993-A1 | CYCLIC TRIAZO SODIUM CHANNEL BLOCKERS | UNIVERSITY OF GREENWICH (GB) | 2012-05-31 | — | — | US | disclosed |
| US-20120135993-A1 | CYCLIC TRIAZO SODIUM CHANNEL BLOCKERS | UNIVERSITY OF GREENWICH (GB) | 2012-05-31 | — | — | US | disclosed |
| WO-2011004196-A1 | CYCLIC TRIAZO SODIUM CHANNEL BLOCKERS | UNIVERSITY OF GREENWICH (GB) | 2011-01-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120135993-A1 | CYCLIC TRIAZO SODIUM CHANNEL BLOCKERS | SCN1B, HCN3, SCN5A | ALDH1A1 2516/4885L3MBTL1 3281/4885HSD11B1 604/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.