Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 7/20 | 0.46 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 4/20 | 0.39 |
| ▸ | RAB9A | P51151 | 3/20 | 0.39 |
| ▸ | PARP1 | P09874 | 6/20 | 0.38 |
| ▸ | PARP2 | Q9UGN5 | 4/20 | 0.38 |
| ▸ | CDK12 | Q9NYV4 | 3/20 | 0.38 |
| ▸ | MAOB | P27338 | 1/20 | 0.38 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.38 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.38 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | CDK1 | P06493 | 1/20 | 0.37 |
| ▸ | CDK2 | P24941 | 1/20 | 0.37 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8261440 | 0.95 | RIPK1 (0.40) | CNR2RIPK1NPC1RAB9APARP1 | |
| SCHEMBL9611635 | 0.84 | RIPK1 (0.43) | CNR2RIPK1NPC1RAB9APARP1 | |
| SCHEMBL1202466 | 0.84 | RIPK1 (0.40) | RIPK1NPC1RAB9APARP1PARP2 | |
| SCHEMBL8258916 | 0.82 | MAOB (0.47) | NPC1RAB9APARP1MAOBADORA2A | |
| SCHEMBL1201079 | 0.82 | RIPK1 (0.38) | RIPK1NPC1RAB9APARP1PARP2 | |
| SCHEMBL1202353 | 0.82 | MAOB (0.42) | NPC1RAB9APARP1MAOBADORA2A | |
| SCHEMBL1202273 | 0.81 | MAOB (0.45) | CNR2NPC1RAB9APARP1PARP2 | |
| SCHEMBL1202393 | 0.81 | NPC1 (0.37) | CNR2RIPK1NPC1RAB9APARP1 | |
| SCHEMBL1202400 | 0.80 | PTGES (0.39) | RIPK1NPC1RAB9APARP1PARP2 | |
| SCHEMBL12845969 | 0.80 | CNR2 (0.44) | CNR2NPC1RAB9APARP1PARP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2457901-A1 | Benzazole derivatives, compositions, and methods of use as B-secretase inhibitors | High Point Pharmaceuticals, LLC (US) | 2012-05-30 | — | — | EP | disclosed |