Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 3/20 | 0.53 |
| ▸ | PPARA | Q07869 | 3/20 | 0.53 |
| ▸ | IGLV6-57 | P01721 | 1/20 | 0.52 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.44 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.43 |
| ▸ | CASR | P41180 | 1/20 | 0.43 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.43 |
| ▸ | ALKBH1 | Q13686 | 1/20 | 0.43 |
| ▸ | AKR1C3 | P42330 | 3/20 | 0.42 |
| ▸ | AKR1C2 | P52895 | 3/20 | 0.42 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.42 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26190199 | 0.90 | PPARG (0.49) | PPARGPPARAIGLV6-57PTPN7CYP1A2 | |
| SCHEMBL2785535 | 0.81 | SLC6A4 (0.59) | IGLV6-57CYP1A2RAB9ASLC6A4SLC7A5 | |
| SCHEMBL5394251 | 0.81 | HTR2A (0.45) | PPARGPPARAPTPN7CYP1A2CYP2A6 | |
| SCHEMBL25913827 | 0.81 | SLC6A4 (0.51) | IGLV6-57CYP1A2RAB9ASLC6A4SLC7A5 | |
| SCHEMBL6006366 | 0.80 | SLC6A4 (0.49) | PPARGPPARAPTPN7SLC6A4SLC7A5 | |
| SCHEMBL7549785 | 0.79 | SLC6A4 (0.53) | IGLV6-57CYP1A2RAB9ASLC6A4SLC7A5 | |
| SCHEMBL10021745 | 0.79 | IGLV6-57 (0.51) | IGLV6-57CYP1A2RAB9ASLC6A4SLC7A5 | |
| SCHEMBL5308268 | 0.79 | PPARG (0.43) | PPARGPPARAPTPN7CYP1A2CYP2A6 | |
| SCHEMBL5176292 | 0.78 | ALDH1A1 (0.57) | IGLV6-57SLC6A4SLC7A5ALKBH1 | |
| SCHEMBL20526950 | 0.78 | IGLV6-57 (0.51) | IGLV6-57SLC6A4SLC7A5ALKBH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5135947-A | Treatment of depression, eating disorders, and alcoholism | ELI LILLY AND COMPANY (US) | 1992-08-04 | — | — | US | disclosed |
| EP-0288188-B1 | 1-PHENYL-3-NAPHTHALENYLOXY-PROPANAMINES | ELI LILLY AND COMPANY (US) | 1991-10-16 | — | — | EP | disclosed |
| EP-0288188-A1 | 1-Phenyl-3-naphthalenyloxy-propanamines | ELI LILLY AND COMPANY (US) | 1988-10-26 | — | — | EP | disclosed |