Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 12/20 | 0.57 |
| ▸ | PPARA | Q07869 | 11/20 | 0.57 |
| ▸ | ALOX5 | P09917 | 10/20 | 0.57 |
| ▸ | PTGES | O14684 | 7/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.54 |
| ▸ | MAPT | P10636 | 3/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | ATM | Q13315 | 1/20 | 0.48 |
| ▸ | MMP2 | P08253 | 1/20 | 0.46 |
| ▸ | MMP9 | P14780 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | RECQL | P46063 | 1/20 | 0.44 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9858577 | 0.83 | PPARG (0.58) | PPARGPPARAALOX5PTGESALDH1A1 | |
| SCHEMBL9614105 | 0.82 | PPARG (0.63) | PPARGPPARAALOX5PTGESALDH1A1 | |
| SCHEMBL10419970 | 0.81 | ALOX5 (0.55) | PPARGPPARAALOX5PTGESALDH1A1 | |
| SCHEMBL10419418 | 0.81 | ALOX5 (0.55) | PPARGPPARAALOX5PTGESALDH1A1 | |
| SCHEMBL9613848 | 0.81 | PPARG (0.81) | PPARGPPARAALOX5PTGESALDH1A1 | |
| SCHEMBL10420221 | 0.81 | ALOX5 (0.55) | PPARGPPARAALOX5PTGESALDH1A1 | |
| SCHEMBL9613827 | 0.79 | PPARG (0.73) | PPARGPPARAALOX5PTGESALDH1A1 | |
| SCHEMBL20886629 | 0.79 | PPARG (0.66) | PPARGPPARAALOX5PTGESALDH1A1 | |
| SCHEMBL10419188 | 0.78 | PPARG (0.52) | PPARGPPARAALOX5PTGESALDH1A1 | |
| SCHEMBL9695329 | 0.78 | PPARG (0.52) | PPARGPPARAALOX5PTGESALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5145611-A | Diabetes | BOEHRINGER MANNHEIM GMBH (DE) | 1992-09-08 | — | — | US | disclosed |
| EP-0279162-B1 | CARBONIC ACID DERIVATIVES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICALS CONTAINING THEM | Roche Diagnostics GmbH (DE) | 1991-06-19 | — | — | EP | disclosed |
| EP-0279162-A1 | Carbonic acid derivatives, process for their preparation and pharmaceuticals containing them | Roche Diagnostics GmbH (DE) | 1988-08-24 | — | — | EP | disclosed |