Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 12/20 | 0.58 |
| ▸ | PPARA | Q07869 | 12/20 | 0.58 |
| ▸ | ALOX5 | P09917 | 10/20 | 0.58 |
| ▸ | PTGES | O14684 | 7/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | MMP2 | P08253 | 1/20 | 0.50 |
| ▸ | MMP9 | P14780 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9614217 | 0.83 | PPARG (0.57) | PPARGPPARAALOX5PTGESALDH1A1 | |
| SCHEMBL9858491 | 0.83 | PPARG (0.75) | PPARGPPARAALOX5PTGESALDH1A1 | |
| SCHEMBL9613827 | 0.82 | PPARG (0.73) | PPARGPPARAALOX5PTGESALDH1A1 | |
| SCHEMBL10419970 | 0.81 | ALOX5 (0.55) | PPARGPPARAALOX5PTGESALDH1A1 | |
| SCHEMBL10420221 | 0.81 | ALOX5 (0.55) | PPARGPPARAALOX5PTGESALDH1A1 | |
| SCHEMBL10419418 | 0.81 | ALOX5 (0.55) | PPARGPPARAALOX5PTGESALDH1A1 | |
| SCHEMBL3035290 | 0.81 | PPARG (0.50) | PPARGPPARAALOX5PTGESALDH1A1 | |
| SCHEMBL9614105 | 0.80 | PPARG (0.63) | PPARGPPARAALOX5PTGESALDH1A1 | |
| SCHEMBL5171584 | 0.79 | ALDH1A1 (0.58) | ALDH1A1KMT2AMAPTLMNAMEN1 | |
| SCHEMBL9613848 | 0.78 | PPARG (0.81) | PPARGPPARAALOX5PTGESALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0279162-B1 | CARBONIC ACID DERIVATIVES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICALS CONTAINING THEM | Roche Diagnostics GmbH (DE) | 1991-06-19 | — | — | EP | disclosed |
| EP-0279162-A1 | Carbonic acid derivatives, process for their preparation and pharmaceuticals containing them | Roche Diagnostics GmbH (DE) | 1988-08-24 | — | — | EP | disclosed |