Known targets — ChEMBL curated mechanism
SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9A
The experimentally established mechanism targets of Procainamide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN1A known ✓ | P35498 | 1/20 | 0.60 |
| ▸ | SCN2A known ✓ | Q99250 | 1/20 | 0.60 |
| ▸ | SCN3A known ✓ | Q9NY46 | 1/20 | 0.60 |
| ▸ | BLM | P54132 | 3/20 | 1.00 |
| ▸ | LMNA | P02545 | 2/20 | 1.00 |
| ▸ | PMP22 | Q01453 | 1/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.97 |
| ▸ | TSHR | P16473 | 2/20 | 0.97 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.97 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.97 |
| ▸ | ACHE | P22303 | 1/20 | 0.97 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.97 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.97 |
| ▸ | POLB | P06746 | 2/20 | 0.68 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.68 |
| ▸ | THRB | P10828 | 1/20 | 0.68 |
| ▸ | ATM | Q13315 | 1/20 | 0.68 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.68 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.65 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Procainamide SCHEMBL40758 | 1.00 | BLM (1.00) | BLMLMNAPMP22ALDH1A1TSHR | |
| Procainamide SCHEMBL10717171 | 0.98 | BLM (0.97) | BLMLMNAPMP22ALDH1A1TSHR | |
| Procainamide SCHEMBL9592794 | 0.98 | BLM (0.97) | BLMLMNAPMP22ALDH1A1TSHR | |
| Procainamide SCHEMBL5443536 | 0.98 | BLM (0.97) | BLMLMNAPMP22ALDH1A1TSHR | |
| Procainamide SCHEMBL9437783 | 0.98 | BLM (0.97) | BLMLMNAPMP22ALDH1A1TSHR | |
| Procainamide SCHEMBL23270847 | 0.98 | BLM (0.97) | BLMLMNAPMP22ALDH1A1TSHR | |
| Procainamide SCHEMBL9618624 | 0.98 | BLM (0.97) | BLMLMNAPMP22ALDH1A1TSHR | |
| Procainamide SCHEMBL15914 | 0.98 | ALDH1A1 (1.00) | BLMLMNAPMP22ALDH1A1TSHR | |
| Procainamide SCHEMBL28944214 | 0.97 | ALDH1A1 (0.97) | BLMLMNAPMP22ALDH1A1TSHR | |
| Procainamide SCHEMBL341750 | 0.95 | ALDH1A1 (0.94) | BLMLMNAPMP22ALDH1A1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0460064-A4 | THERAPEUTIC AEROSOL FORMULATIONS | — | 1992-04-01 | — | — | EP | disclosed |
| EP-0460064-A1 | THERAPEUTIC AEROSOL FORMULATIONS | RORER INTERNATIONAL (HOLDINGS), INC. (US) | 1991-12-11 | — | — | EP | disclosed |
| WO-1990009781-A1 | THERAPEUTIC AEROSOL FORMULATIONS | RORER INTERNATIONAL (HOLDINGS), INC. (US) | 1990-09-07 | — | — | WO | disclosed |