Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT2 | Q8IXJ6 | 11/20 | 0.64 |
| ▸ | SIRT1 | Q96EB6 | 5/20 | 0.64 |
| ▸ | PGR | P06401 | 1/20 | 0.43 |
| ▸ | RORA | P35398 | 1/20 | 0.43 |
| ▸ | RORC | P51449 | 1/20 | 0.43 |
| ▸ | RORB | Q92753 | 1/20 | 0.43 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.42 |
| ▸ | HTR2A | P28223 | 2/20 | 0.42 |
| ▸ | HTR2C | P28335 | 2/20 | 0.42 |
| ▸ | HTR7 | P34969 | 2/20 | 0.42 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.42 |
| ▸ | HRH1 | P35367 | 2/20 | 0.42 |
| ▸ | HTR6 | P50406 | 2/20 | 0.42 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.41 |
| ▸ | DRD2 | P14416 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL9615130 | 0.99 | SIRT2 (0.62) | SIRT2SIRT1PGRRORARORC | |
| SCHEMBL9696716 | 0.87 | SIRT2 (0.55) | SIRT2SIRT1HRH1HTR6CYP3A4 | |
| SCHEMBL9615110 | 0.84 | NPC1 (0.54) | SIRT2SIRT1ADRA2AHTR2AHTR2C | |
| Hydrochloric Acid SCHEMBL9615105 | 0.82 | KDM4E (0.53) | SIRT2SIRT1ADRA2AHTR2AHTR2C | |
| SCHEMBL15536943 | 0.78 | SIRT2 (1.00) | SIRT2SIRT1 | |
| Hydrochloric Acid SCHEMBL8820362 | 0.78 | SIRT2 (0.43) | SIRT2SIRT1ADRA2AHTR2AHTR2C | |
| SCHEMBL9396418 | 0.77 | SIRT2 (0.46) | SIRT2SIRT1ADRA2AHTR2AHTR2C | |
| SCHEMBL13654434 | 0.77 | HRH1 (0.67) | SIRT2SIRT1ADRA2AHTR2AHTR2C | |
| SCHEMBL15549479 | 0.76 | SIRT2 (0.68) | SIRT2SIRT1HRH1HTR6CYP3A4 | |
| SCHEMBL15550724 | 0.76 | SIRT2 (0.67) | SIRT2SIRT1CYP3A4NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5169852-A | Anorexigenic agents | NEUREX CORPORATION (US) | 1992-12-08 | — | — | US | disclosed |
| EP-0520987-A4 | METHOD OF SUPPRESSING APPETITE BY ADMINISTRATION OF TETRAHYDRO--g(b)-CARBOLINE DERIVATIVES. | NEUREX CORP (US) | 1992-05-13 | — | — | EP | disclosed |