SCHEMBL9615161

SCHEMBL9615161

O=C1C(c2cccc(C(F)(F)F)c2)CCN1c1ccccc1

nearest known ligand 0.47

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
ROCK2 O75116 4/20 0.47
TACR1 P25103 1/20 0.46
KCNH2 Q12809 1/20 0.46
CA12 O43570 1/20 0.46
CA1 P00915 1/20 0.46
CA2 P00918 1/20 0.46
CA9 Q16790 1/20 0.46
DRD2 P14416 1/20 0.45
NOTUM Q6P988 1/20 0.44
KDM4E B2RXH2 1/20 0.44
ALDH1A1 P00352 1/20 0.44
MAPK1 P28482 1/20 0.44
HSD17B10 Q99714 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9615162 0.92 CA12 (0.51) ROCK2KCNH2CA12CA1CA2
SCHEMBL17080024 0.89 ROCK2 (0.47) ROCK2CA12CA1CA2CA9
SCHEMBL17080053 0.82 ROCK2 (0.44) ROCK2CA12CA1CA2CA9
SCHEMBL4721528 0.81 ROCK2 (0.62) ROCK2CA12CA1CA2CA9
SCHEMBL17080048 0.80 ROCK2 (0.41) ROCK2TACR1KCNH2CA12CA1
SCHEMBL7611284 0.75 CA12 (0.55) KCNH2CA12CA1CA2CA9
SCHEMBL7607804 0.75 CA12 (0.55) KCNH2CA12CA1CA2CA9
SCHEMBL7610183 0.75 CA12 (0.55) KCNH2CA12CA1CA2CA9
SCHEMBL909528 0.75 HTR2C (0.43) DRD2
SCHEMBL965009 0.74 CA12 (0.54) CA12CA1CA2CA9DRD2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
JP-4117307-A None JP disclosed
JP-H04117307-A HERBICIDE COMPOSITION FOR PADDY FIELD MITSUI TOATSU CHEM INC 1992-04-17 JP disclosed