Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA7 | P36544 | 5/20 | 0.43 |
| ▸ | CHRNA10 | Q9GZZ6 | 4/20 | 0.43 |
| ▸ | CHRNA9 | Q9UGM1 | 4/20 | 0.43 |
| ▸ | HTR2A | P28223 | 3/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.39 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.39 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.39 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.39 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL8660307 | 0.93 | CHRNA7 (0.47) | CHRNA7CHRNA10CHRNA9MEN1TP53 | |
| Hydrochloric Acid SCHEMBL8070163 | 0.93 | CHRNA7 (0.47) | CHRNA7CHRNA10CHRNA9MEN1TP53 | |
| SCHEMBL3735925 | 0.80 | CYP1A2 (0.51) | CHRNA7CHRNA10CHRNA9HTR2ACYP1A2 | |
| Hydrochloric Acid SCHEMBL32674559 | 0.79 | KMT2A (0.55) | CHRNA7CHRNA10CHRNA9HTR2AMEN1 | |
| Hydrochloric Acid SCHEMBL7145938 | 0.79 | SMN1; SMN2 (0.47) | CHRNA7CHRNA10CHRNA9HTR2AMAPT | |
| Hydrochloric Acid SCHEMBL7145936 | 0.79 | SMN1; SMN2 (0.47) | CHRNA7CHRNA10CHRNA9HTR2AMAPT | |
| Hydrochloric Acid SCHEMBL8070951 | 0.79 | KMT2A (0.55) | CHRNA7CHRNA10CHRNA9HTR2AMEN1 | |
| Hydrochloric Acid SCHEMBL4886622 | 0.77 | CHRNA7 (0.40) | CHRNA7CHRNA10CHRNA9HTR2ACYP1A2 | |
| SCHEMBL11081808 | 0.77 | DNM1 (0.54) | CHRNA7CHRNA10CHRNA9HTR2AMEN1 | |
| SCHEMBL22506081 | 0.76 | CHRNA7 (0.39) | CHRNA7CHRNA10CHRNA9CYP1A2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5104778-A | Layer containing anionic dye, cationic polymer mordant, and gelatin | FUJI PHOTO FILM CO., LTD. (JP) | 1992-04-14 | — | — | US | disclosed |
| US-4948711-A | FIXING SOLUTION CONTAINING A CATIONIC ADDITION POLYMER TO RMOVE IODIDE IONS IN HIGH SPEED CONTINUOUS PROCESSING; EFFICIENCY | FUJI PHOTO FILM CO., LTD. (JP) | 1990-08-14 | — | — | US | disclosed |