Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.58 |
| ▸ | HTT | P42858 | 2/20 | 0.58 |
| ▸ | PFKFB3 | Q16875 | 1/20 | 0.58 |
| ▸ | NPC1 | O15118 | 1/20 | 0.56 |
| ▸ | RAB9A | P51151 | 1/20 | 0.56 |
| ▸ | FABP4 | P15090 | 2/20 | 0.55 |
| ▸ | WDR5 | P61964 | 1/20 | 0.55 |
| ▸ | FABP5 | Q01469 | 1/20 | 0.55 |
| ▸ | RORC | P51449 | 1/20 | 0.54 |
| ▸ | GAA | P10253 | 1/20 | 0.54 |
| ▸ | BRD4 | O60885 | 1/20 | 0.54 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.53 |
| ▸ | GHSR | Q92847 | 1/20 | 0.52 |
| ▸ | PGR | P06401 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8276260 | 0.85 | TSHR (0.54) | TSHRALDH1A1SMN1; SMN2HTTPFKFB3 | |
| SCHEMBL9616673 | 0.81 | WDR5 (0.53) | ALDH1A1SMN1; SMN2HTTNPC1RAB9A | |
| SCHEMBL6206726 | 0.80 | TSHR (0.57) | TSHRALDH1A1HTTPFKFB3FABP4 | |
| SCHEMBL6206728 | 0.80 | TSHR (0.57) | TSHRALDH1A1HTTPFKFB3FABP4 | |
| SCHEMBL6206539 | 0.80 | TSHR (0.57) | TSHRALDH1A1HTTPFKFB3FABP4 | |
| SCHEMBL259694 | 0.80 | MAPT (0.60) | TSHRALDH1A1HTTPFKFB3BRD4 | |
| SCHEMBL3259317 | 0.80 | ALDH1A1 (0.64) | TSHRALDH1A1HTTPFKFB3RORC | |
| SCHEMBL28675136 | 0.80 | TSHR (0.60) | TSHRALDH1A1HTTPFKFB3FABP4 | |
| SCHEMBL13705540 | 0.80 | ALDH1A1 (0.57) | ALDH1A1SMN1; SMN2HTTFABP4WDR5 | |
| SCHEMBL13602254 | 0.80 | PFKFB3 (0.63) | TSHRALDH1A1HTTPFKFB3WDR5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0462179-A4 | NOVEL SULFONAMIDES AS RADIOSENSITIZERS | — | 1992-03-18 | — | — | EP | claimed |
| EP-0462179-A1 | NOVEL SULFONAMIDES AS RADIOSENSITIZERS | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1991-12-27 | — | — | EP | claimed |
| WO-1990009787-A1 | NOVEL SULFONAMIDES AS RADIOSENSITIZERS | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1990-09-07 | — | — | WO | claimed |
| EP-0462179-A4 | NOVEL SULFONAMIDES AS RADIOSENSITIZERS | — | 1992-03-18 | — | — | EP | disclosed |
| EP-0462179-A1 | NOVEL SULFONAMIDES AS RADIOSENSITIZERS | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1991-12-27 | — | — | EP | disclosed |
| WO-1990009787-A1 | NOVEL SULFONAMIDES AS RADIOSENSITIZERS | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1990-09-07 | — | — | WO | disclosed |