Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
| ▸ | HDAC6 | Q9UBN7 | 5/20 | 0.48 |
| ▸ | PARP1 | P09874 | 1/20 | 0.47 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | F2 | P00734 | 6/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | FABP4 | P15090 | 1/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.40 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.40 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.40 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.40 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.40 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.40 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9616610 | 0.79 | WDR5 (0.53) | MEN1KMT2AHDAC6FABP4HDAC3 | |
| SCHEMBL19215380 | 0.74 | MEN1 (1.00) | MEN1KMT2AHDAC6PARP1PARP10 | |
| SCHEMBL10113624 | 0.73 | MEN1 (0.68) | MEN1KMT2AHDAC6PARP1PARP10 | |
| SCHEMBL10113893 | 0.73 | MEN1 (0.68) | MEN1KMT2AHDAC6PARP1PARP10 | |
| SCHEMBL13370421 | 0.71 | MEN1 (0.81) | MEN1KMT2AHDAC6PARP1PARP10 | |
| SCHEMBL9616673 | 0.71 | WDR5 (0.53) | MEN1KMT2AALDH1A1LMNATP53 | |
| SCHEMBL9453278 | 0.70 | MEN1 (0.83) | MEN1KMT2AHDAC6PARP1PARP10 | |
| SCHEMBL882827 | 0.70 | MEN1 (0.83) | MEN1KMT2AHDAC6PARP1PARP10 | |
| SCHEMBL9616544 | 0.69 | WDR5 (0.67) | MEN1KMT2AFABP4MAPT | |
| SCHEMBL14567079 | 0.69 | KMT2A (0.88) | MEN1KMT2AHDAC6PARP1PARP10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0462179-A4 | NOVEL SULFONAMIDES AS RADIOSENSITIZERS | — | 1992-03-18 | — | — | EP | claimed |
| EP-0462179-A1 | NOVEL SULFONAMIDES AS RADIOSENSITIZERS | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1991-12-27 | — | — | EP | claimed |
| WO-1990009787-A1 | NOVEL SULFONAMIDES AS RADIOSENSITIZERS | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1990-09-07 | — | — | WO | claimed |