Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.56 |
| ▸ | HTT | P42858 | 1/20 | 0.56 |
| ▸ | PFKFB3 | Q16875 | 1/20 | 0.56 |
| ▸ | PGR | P06401 | 2/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.56 |
| ▸ | TSHR | P16473 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
| ▸ | GHSR | Q92847 | 1/20 | 0.53 |
| ▸ | FADS1 | O60427 | 1/20 | 0.53 |
| ▸ | TYMS | P04818 | 1/20 | 0.52 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.51 |
| ▸ | RORA | P35398 | 1/20 | 0.51 |
| ▸ | RORC | P51449 | 1/20 | 0.51 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.51 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.51 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL812673 | 0.84 | TSHR (0.74) | ALDH1A1HTTPFKFB3PGRKMT2A | |
| SCHEMBL31110643 | 0.84 | TSHR (0.74) | ALDH1A1HTTPFKFB3PGRKMT2A | |
| SCHEMBL3259317 | 0.82 | ALDH1A1 (0.64) | ALDH1A1HTTPFKFB3PGRTSHR | |
| SCHEMBL9616624 | 0.82 | ALDH1A1 (0.56) | ALDH1A1HTTPFKFB3PGRTSHR | |
| SCHEMBL259694 | 0.82 | MAPT (0.60) | ALDH1A1HTTPFKFB3PGRKMT2A | |
| SCHEMBL9480187 | 0.81 | ALDH1A1 (0.62) | ALDH1A1HTTPFKFB3PGRTSHR | |
| SCHEMBL7451084 | 0.80 | KMT2A (0.65) | ALDH1A1PGRKMT2ATSHRMEN1 | |
| SCHEMBL9616708 | 0.79 | MEN1 (0.64) | ALDH1A1HTTPFKFB3PGRKMT2A | |
| SCHEMBL9616551 | 0.78 | MAPT (0.54) | ALDH1A1HTTPFKFB3PGRTSHR | |
| SCHEMBL9478942 | 0.78 | TSHR (0.71) | ALDH1A1HTTPFKFB3PGRKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0462179-A4 | NOVEL SULFONAMIDES AS RADIOSENSITIZERS | — | 1992-03-18 | — | — | EP | claimed |
| EP-0462179-A1 | NOVEL SULFONAMIDES AS RADIOSENSITIZERS | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1991-12-27 | — | — | EP | claimed |
| WO-1990009787-A1 | NOVEL SULFONAMIDES AS RADIOSENSITIZERS | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1990-09-07 | — | — | WO | claimed |
| EP-0462179-A4 | NOVEL SULFONAMIDES AS RADIOSENSITIZERS | — | 1992-03-18 | — | — | EP | disclosed |
| EP-0462179-A1 | NOVEL SULFONAMIDES AS RADIOSENSITIZERS | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1991-12-27 | — | — | EP | disclosed |
| WO-1990009787-A1 | NOVEL SULFONAMIDES AS RADIOSENSITIZERS | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1990-09-07 | — | — | WO | disclosed |