Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Proline. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ELANE | P08246 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | SCN4A | P35499 | 1/20 | 0.35 |
| ▸ | DPP4 | P27487 | 2/20 | 0.35 |
| ▸ | HTR2C | P28335 | 2/20 | 0.34 |
| ▸ | HTR2B | P41595 | 2/20 | 0.34 |
| ▸ | HTR2A | P28223 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.33 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Proline SCHEMBL28069465 | 0.78 | MEN1 (0.45) | KDM4ECYP1A2CYP3A4CYP2D6CYP2C19 | |
| Proline SCHEMBL16394427 | 0.74 | BLM (0.48) | ELANECYP1A2CYP2D6CYP2C19SCN4A | |
| Proline SCHEMBL28049461 | 0.74 | MEN1 (0.48) | CYP2D6SCN4ADPP4TSHRDPP8 | |
| Proline SCHEMBL10141181 | 0.74 | — | — | |
| Proline SCHEMBL6894672 | 0.74 | BLM (0.52) | CYP1A2CYP2D6CYP2C19DPP4SMN1; SMN2 | |
| Proline SCHEMBL18875607 | 0.74 | — | — | |
| Proline SCHEMBL10141185 | 0.74 | — | — | |
| Proline SCHEMBL6894675 | 0.74 | BLM (0.52) | CYP1A2CYP2D6CYP2C19DPP4SMN1; SMN2 | |
| D-Proline SCHEMBL21462052 | 0.74 | BLM (0.52) | CYP1A2CYP2D6CYP2C19DPP4SMN1; SMN2 | |
| Proline SCHEMBL7792 | 0.74 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-H1056-H | Luteinizing hormone-releasing hormone | RHONE-POULENC CHIMIE, SERVICE BREVETS CHIMIE (FR) | 1992-05-05 | — | — | US | disclosed |
| EP-0399885-A1 | Tripeptide, its process of preparation and its use | RHONE-POULENC CHIMIE (FR) | 1990-11-28 | — | — | EP | disclosed |