Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.36 |
| ▸ | HTR3B | O95264 | 1/20 | 0.36 |
| ▸ | HTR3A | P46098 | 1/20 | 0.36 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.36 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.36 |
| ▸ | F11 | P03951 | 5/20 | 0.35 |
| ▸ | KLKB1 | P03952 | 5/20 | 0.35 |
| ▸ | PSEN1 | P49768 | 11/20 | 0.34 |
| ▸ | PSEN2 | P49810 | 11/20 | 0.34 |
| ▸ | APH1B | Q8WW43 | 11/20 | 0.34 |
| ▸ | NCSTN | Q92542 | 11/20 | 0.34 |
| ▸ | APH1A | Q96BI3 | 11/20 | 0.34 |
| ▸ | PSENEN | Q9NZ42 | 11/20 | 0.34 |
| ▸ | NOS3 | P29474 | 3/20 | 0.34 |
| ▸ | NOS1 | P29475 | 3/20 | 0.34 |
| ▸ | NOS2 | P35228 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12918170 | 1.00 | HTR3E (0.36) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL12918125 | 0.84 | PSEN1 (0.43) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL12918119 | 0.84 | NOS3 (0.42) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| Iodide SCHEMBL963916 | 0.84 | PSEN1 (0.43) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| Iodide SCHEMBL961138 | 0.83 | NOS3 (0.43) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL964114 | 0.78 | PSEN1 (0.35) | F11KLKB1PSEN1PSEN2APH1B | |
| SCHEMBL514297 | 0.77 | NR4A1 (0.46) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL961602 | 0.74 | PSEN1 (0.44) | F11KLKB1PSEN1PSEN2APH1B | |
| Iodide SCHEMBL962860 | 0.74 | PSEN1 (0.42) | F11KLKB1PSEN1PSEN2APH1B | |
| SCHEMBL12918137 | 0.73 | HTR3E (0.40) | HTR3EHTR3BHTR3AHTR3DHTR3C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2379553-B1 | BICYCLIC COMPOUNDS FOR THE REDUCTION OF BETA-AMYLOID PRODUCTION | BRISTOL MYERS SQUIBB CO (US) | 2013-06-26 | — | — | EP | disclosed |
| US-8349880-B2 | Bicyclic compounds for the reduction of beta-amyloid production | BRISTOL-MYERS SQUIBB COMPANY (US) | 2013-01-08 | — | — | US | disclosed |
| US-20110015175-A1 | Bicyclic Compounds for the Reduction of Beta-Amyloid Production | BRISTOL-MYERS SQUIBB COMPANY | 2011-01-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110015175-A1 | Bicyclic Compounds for the Reduction of Beta-Amyloid Production | APP, BACE1, APBA1 | HTR3E 3947/4885HTR3B 2529/4885HTR3A 3099/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.