Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRD5A1 | P18405 | 12/20 | 0.44 |
| ▸ | SRD5A2 | P31213 | 8/20 | 0.44 |
| ▸ | MBOAT4 | Q96T53 | 3/20 | 0.43 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.36 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9708876 | 0.94 | SRD5A1 (0.42) | SRD5A1SRD5A2MBOAT4 | |
| SCHEMBL8677535 | 0.88 | MBOAT4 (0.40) | SRD5A1SRD5A2MBOAT4GRIN1GRIN2B | |
| SCHEMBL9543229 | 0.87 | MBOAT4 (0.41) | SRD5A1SRD5A2MBOAT4 | |
| SCHEMBL9776615 | 0.87 | SRD5A1 (0.41) | SRD5A1SRD5A2MBOAT4 | |
| SCHEMBL7643438 | 0.84 | MBOAT4 (0.47) | SRD5A1SRD5A2MBOAT4GRIN1GRIN2B | |
| SCHEMBL10698417 | 0.82 | MBOAT4 (0.45) | SRD5A1SRD5A2MBOAT4GRIN1GRIN2B | |
| SCHEMBL9580259 | 0.80 | SRD5A1 (0.45) | SRD5A1SRD5A2MBOAT4GRIN1GRIN2B | |
| SCHEMBL5109022 | 0.78 | MBOAT4 (0.51) | SRD5A1SRD5A2MBOAT4GRIN1GRIN2B | |
| SCHEMBL5580932 | 0.78 | MBOAT4 (0.41) | SRD5A1SRD5A2MBOAT4GRIN1GRIN2B | |
| SCHEMBL9134492 | 0.77 | MBOAT4 (0.40) | SRD5A1SRD5A2MBOAT4GRIN1GRIN2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0414491-A2 | 17 Beta-acyl-4-aza-5 alpha-androst-1-ene-3-ones as 5 alpha-reductase inhibitors | MERCK & CO. INC. (US) | 1991-02-27 | — | — | EP | claimed |
| JP-4288096-A | — | — | None | — | — | JP | disclosed |
| US-5162332-A | Selected 17 β-polyaroyl-4-aza-5 α-androst-1-en-3-ones as steroidal reductase inhibitors | MERCK & CO., INC. (US) | 1992-11-10 | — | — | US | disclosed |
| JP-H04288096-A | NEW PRODUCTION METHOD OF 3-OXO-4-AZA-ANDROST-1-ENE 17 BETA-KETONE | MERCK & CO INC | 1992-10-13 | — | — | JP | disclosed |
| US-5098908-A | 17β-hydroxybenzoyl-4-aza-5α-androst-1-en-3-ones as testosterone reductase inhibitors | MERCK & CO., INC. (US) | 1992-03-24 | — | — | US | disclosed |
| EP-0462661-A2 | Novel 17beta-hydroxybenzoyl-4-aza-5alpha-androst-1-en-3-ones as testosterone reductase inhibitors | MERCK & CO. INC. (US) | 1991-12-27 | — | — | EP | disclosed |
| EP-0462665-A2 | Selected 17beta-polyaroyl-4-aza-5alpha-androst-1-en-3-ones as steroidal reductase inhibitors | MERCK & CO. INC. (US) | 1991-12-27 | — | — | EP | disclosed |
| EP-0462668-A2 | New 17beta-aminobenzoyl-4-aza-5alpha-androst-1-en-3-ones as benign prostatic hypertrophy agents | MERCK & CO. INC. (US) | 1991-12-27 | — | — | EP | disclosed |
| US-5061802-A | 17β-aminobenzoyl-4-aza-5α-androst-1-en-3-ones as benign prostatic hypertrophy agents | MERCK & CO. INC. (US) | 1991-10-29 | — | — | US | disclosed |