SCHEMBL9618481

SCHEMBL9618481

FC(F)(F)c1ccc(CNc2nccs2)cc1

nearest known ligand 0.60

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SCN3A Q9NY46 4/20 0.60
SMN1; SMN2 Q16637 1/20 0.55
ASPH Q12797 1/20 0.45
KDM8 Q8N371 1/20 0.45
HDAC3 O15379 1/20 0.45
HDAC1 Q13547 1/20 0.45
HDAC2 Q92769 1/20 0.45
HDAC6 Q9UBN7 1/20 0.45
ALDH1A1 P00352 3/20 0.44
KDM4E B2RXH2 3/20 0.44
HPGD P15428 1/20 0.44
L3MBTL1 Q9Y468 1/20 0.44
FBP1 P09467 1/20 0.44
EPHX2 P34913 1/20 0.44
MAPT P10636 2/20 0.43
TDP1 Q9NUW8 1/20 0.43
TP53 P04637 1/20 0.43
POLB P06746 1/20 0.43
GAA P10253 1/20 0.43
VNN1 O95497 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4602071 0.82 SMN1; SMN2 (0.58) SMN1; SMN2ALDH1A1KDM4EHPGDL3MBTL1
SCHEMBL648507 0.82 MAPT (0.60) SMN1; SMN2ALDH1A1KDM4EHPGDL3MBTL1
SCHEMBL171893 0.79 KDM4E (0.62) SMN1; SMN2ALDH1A1KDM4EHPGDL3MBTL1
SCHEMBL3635025 0.78 KDM4E (0.60) SCN3ASMN1; SMN2KDM4EHPGDL3MBTL1
SCHEMBL11328569 0.77 SCN3A (0.53) SCN3ASMN1; SMN2KDM4EHPGDL3MBTL1
SCHEMBL15011086 0.75 SMN1; SMN2 (0.66) SMN1; SMN2ALDH1A1KDM4EHPGDL3MBTL1
SCHEMBL2688165 0.72 KDM4E (0.55) SMN1; SMN2ALDH1A1KDM4EHPGDL3MBTL1
SCHEMBL30855028 0.72 SMN1; SMN2 (0.51) SMN1; SMN2ALDH1A1KDM4EHPGDL3MBTL1
SCHEMBL3065005 0.71 SCN3A (0.81) SCN3ASMN1; SMN2ALDH1A1KDM4ETDP1
SCHEMBL12264158 0.71 ALDH1A1 (0.49) SCN3ASMN1; SMN2ALDH1A1KDM4EFBP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
JP-4334374-A None JP disclosed
JP-H04334374-A N-(2-THIAZOLYL)UREA DERIVATIVE, ITS PRODUCTION AND INSECTICIDE CONTAINING THE SAME COMPOUND MITSUI TOATSU CHEM INC 1992-11-20 JP disclosed