Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.58 |
| ▸ | ADRA2A | P08913 | 11/20 | 0.46 |
| ▸ | ADRA2B | P18089 | 8/20 | 0.46 |
| ▸ | ADRA2C | P18825 | 8/20 | 0.46 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.40 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.40 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11418621 | 0.92 | NISCH (0.55) | NISCHADRA2AADRA2BADRA2CADRA1D | |
| SCHEMBL11418650 | 0.92 | NISCH (0.55) | NISCHADRA2AADRA2BADRA2CADRA1D | |
| SCHEMBL6054462 | 0.89 | NISCH (0.69) | NISCHADRA2AADRA2BADRA2CADRA1D | |
| SCHEMBL11098729 | 0.77 | NISCH (0.65) | NISCHADRA2AADRA2BADRA2CADRA1D | |
| SCHEMBL8091334 | 0.73 | NISCH (1.00) | NISCHADRA2AADRA2BADRA2CADRA1D | |
| Isaglidole SCHEMBL30659750 | 0.73 | NISCH (0.72) | NISCHADRA2AADRA2BADRA2C | |
| Isaglidole SCHEMBL114184 | 0.73 | NISCH (0.72) | NISCHADRA2AADRA2BADRA2C | |
| SCHEMBL11001474 | 0.73 | NISCH (0.72) | NISCHADRA2AADRA2BADRA2CADRA1D | |
| SCHEMBL11435767 | 0.72 | NISCH (0.60) | NISCHADRA2AADRA2BADRA2CADRA1D | |
| Hydrochloric Acid SCHEMBL6513698 | 0.72 | NISCH (0.97) | NISCHADRA2AADRA2BADRA2CADRA1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0254777-B1 | Use of imidazolinylaminoisoindolines and related compounds for the manufacture of a medicament for the treatment of hyperglycaemia. | BEECHAM GROUP PLC (GB) | 1992-03-04 | — | — | EP | claimed |
| EP-0212783-B1 | USE OF IMIDAZOLINYLAMINOISOINDOLINES AND RELATED COMPOUNDS IN THE TREATMENT OF HYPERGLYCAEMIA | BEECHAM GROUP PLC (GB) | 1992-01-08 | — | — | EP | claimed |
| US-4847280-A | HYPOGLYCEMIC AGENTS | BEECHAM GROUP PLC (GB) | 1989-07-11 | — | — | US | claimed |
| EP-0254777-A2 | Use of imidazolinylaminoisoindolines and related compounds for the manufacture of a medicament for the treatment of hyperglycaemia. | BEECHAM GROUP PLC (GB) | 1988-02-03 | — | — | EP | claimed |
| EP-0212783-A2 | Use of imidazolinylaminoisoindolines and related compounds in the treatment of hyperglycaemia | BEECHAM GROUP PLC (GB) | 1987-03-04 | — | — | EP | claimed |
| EP-0254777-B1 | Use of imidazolinylaminoisoindolines and related compounds for the manufacture of a medicament for the treatment of hyperglycaemia. | BEECHAM GROUP PLC (GB) | 1992-03-04 | — | — | EP | disclosed |
| US-4221798-A | Hypotensive 2-heterocycloamino-imidazolines | BEIERSDORF AKTIENGESELLSCHAFT (DE) | 1980-09-09 | — | — | US | disclosed |