Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.48 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9620630 | 0.94 | ALDH1A1 (0.56) | KMT2AMEN1ALDH1A1TSHRKDM4E | |
| SCHEMBL10735758 | 0.90 | SMN1; SMN2 (0.47) | KMT2AMEN1SMN1; SMN2TSHRKDM4E | |
| Hydrochloric Acid SCHEMBL10568440 | 0.89 | SMN1; SMN2 (0.47) | KMT2AMEN1SMN1; SMN2TSHRKDM4E | |
| SCHEMBL9620317 | 0.89 | PKM (0.56) | PKMKMT2AMEN1ALDH1A1SMN1; SMN2 | |
| SCHEMBL9811288 | 0.87 | KMT2A (0.44) | PKMKMT2AMEN1ALDH1A1SMN1; SMN2 | |
| SCHEMBL9620477 | 0.87 | KMT2A (0.53) | PKMKMT2AMEN1ALDH1A1SMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL9620334 | 0.87 | PKM (0.54) | PKMKMT2AMEN1ALDH1A1KDM4E | |
| SCHEMBL9620614 | 0.83 | ALDH1A1 (0.58) | PKMKMT2AMEN1ALDH1A1SMN1; SMN2 | |
| SCHEMBL2749472 | 0.83 | KMT2A (0.65) | PKMKMT2AMEN1ALDH1A1SMN1; SMN2 | |
| SCHEMBL9620583 | 0.82 | ALDH1A1 (0.57) | PKMKMT2AMEN1ALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0221511-B1 | 2-AMINOSULFONYL-6-NITROBENZOIC ESTERS OR AMIDES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | MERCK & CO. INC. (US) | 1992-01-02 | — | — | EP | claimed |
| EP-0221511-A1 | 2-aminosulfonyl-6-nitrobenzoic esters or amides, process for their preparation and pharmaceutical compositions containing them | MERCK & CO. INC. (US) | 1987-05-13 | — | — | EP | claimed |
| US-4603133-A | Amides and esters of 2-[N-(morpholinoalkyl)aminosulfonyl]-6-nitrobenzoic acids and compositions useful as adjuncts to radiation therapy | MERCK & CO., INC. (US) | 1986-07-29 | — | — | US | claimed |
| EP-0221511-B1 | 2-AMINOSULFONYL-6-NITROBENZOIC ESTERS OR AMIDES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | MERCK & CO. INC. (US) | 1992-01-02 | — | — | EP | disclosed |
| EP-0221511-A1 | 2-aminosulfonyl-6-nitrobenzoic esters or amides, process for their preparation and pharmaceutical compositions containing them | MERCK & CO. INC. (US) | 1987-05-13 | — | — | EP | disclosed |
| US-4603133-A | Amides and esters of 2-[N-(morpholinoalkyl)aminosulfonyl]-6-nitrobenzoic acids and compositions useful as adjuncts to radiation therapy | MERCK & CO., INC. (US) | 1986-07-29 | — | — | US | disclosed |