Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRB | P28702 | 7/20 | 0.47 |
| ▸ | RXRA | P19793 | 7/20 | 0.47 |
| ▸ | MRGPRX4 | Q96LA9 | 3/20 | 0.47 |
| ▸ | RXRG | P48443 | 5/20 | 0.46 |
| ▸ | PTGER1 | P34995 | 3/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | GFER | P55789 | 1/20 | 0.43 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.43 |
| ▸ | KLF5 | Q13887 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | MAOA | P21397 | 2/20 | 0.42 |
| ▸ | MAOB | P27338 | 2/20 | 0.42 |
| ▸ | DHODH | Q02127 | 1/20 | 0.41 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9621327 | 0.94 | CHRNA7 (0.49) | RXRAMRGPRX4NPC1RAB9AMEN1 | |
| SCHEMBL9621006 | 0.94 | CHRNA7 (0.49) | RXRAMRGPRX4NPC1RAB9AMEN1 | |
| SCHEMBL9620986 | 0.92 | FOLH1 (0.46) | RXRBRXRAMRGPRX4RXRGPTGER1 | |
| SCHEMBL7216359 | 0.84 | NPC1 (0.56) | RXRBRXRAMRGPRX4RXRGNPC1 | |
| SCHEMBL9620678 | 0.81 | TSHR (0.41) | NPC1RAB9APOLBMEN1KMT2A | |
| SCHEMBL7222385 | 0.77 | NPC1 (0.55) | RXRBRXRAMRGPRX4RXRGNPC1 | |
| SCHEMBL9621378 | 0.77 | ALDH1A1 (0.53) | NPC1RAB9APOLBL3MBTL1 | |
| SCHEMBL9621005 | 0.76 | KDM4E (0.41) | MAOAKMT2A | |
| SCHEMBL9620829 | 0.76 | ALDH1A1 (0.53) | NPC1RAB9APOLBL3MBTL1 | |
| SCHEMBL9620846 | 0.76 | ALDH1A1 (0.53) | NPC1RAB9APOLBL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0284359-B1 | 1,4-DISUBSTITUTED PIPERAZINE COMPOUNDS, THEIR PRODUCTION AND USE | Takeda Chemical Industries, Ltd. (JP) | 1992-01-08 | — | — | EP | disclosed |
| US-4880809-A | HYPOTENSIVE AGENTS, AMIDE DERIVATIVES | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1989-11-14 | — | — | US | disclosed |
| EP-0284359-A1 | 1,4-Disubstituted piperazine compounds, their production and use | Takeda Chemical Industries, Ltd. (JP) | 1988-09-28 | — | — | EP | disclosed |