Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10565148 | 0.96 | POLB (0.55) | POLBALDH1A1CYP1A2L3MBTL1GAA | |
| SCHEMBL9620765 | 0.95 | POLB (0.56) | POLBALDH1A1CYP1A2L3MBTL1GAA | |
| SCHEMBL9620863 | 0.92 | POLB (0.58) | POLBALDH1A1CYP1A2L3MBTL1GAA | |
| Methyl Alcohol SCHEMBL9782201 | 0.91 | POLB (0.57) | POLBALDH1A1CYP1A2L3MBTL1GAA | |
| SCHEMBL9620811 | 0.90 | POLB (0.58) | POLBALDH1A1CYP1A2L3MBTL1GAA | |
| SCHEMBL9620806 | 0.90 | POLB (0.58) | POLBALDH1A1CYP1A2L3MBTL1GAA | |
| SCHEMBL9620939 | 0.87 | POLB (0.52) | POLBALDH1A1CYP1A2L3MBTL1GAA | |
| SCHEMBL9620842 | 0.86 | ALDH1A1 (0.52) | POLBALDH1A1CYP1A2L3MBTL1GAA | |
| SCHEMBL9621255 | 0.85 | POLB (0.61) | POLBALDH1A1CYP1A2L3MBTL1GAA | |
| SCHEMBL9620850 | 0.83 | KMT2A (0.53) | POLBALDH1A1CYP1A2L3MBTL1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0284359-B1 | 1,4-DISUBSTITUTED PIPERAZINE COMPOUNDS, THEIR PRODUCTION AND USE | Takeda Chemical Industries, Ltd. (JP) | 1992-01-08 | — | — | EP | disclosed |
| US-4880809-A | HYPOTENSIVE AGENTS, AMIDE DERIVATIVES | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1989-11-14 | — | — | US | disclosed |
| EP-0284359-A1 | 1,4-Disubstituted piperazine compounds, their production and use | Takeda Chemical Industries, Ltd. (JP) | 1988-09-28 | — | — | EP | disclosed |