Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.50 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 4/20 | 0.47 |
| ▸ | ACHE | P22303 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | MAOA | P21397 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.44 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.44 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.44 |
| ▸ | TUBB | P07437 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9621112 | 1.00 | KMT2A (0.53) | KMT2AMEN1KDM4EALDH1A1HSD17B1 | |
| SCHEMBL424613 | 0.96 | HSD17B1 (0.54) | KMT2AMEN1KDM4EALDH1A1HSD17B1 | |
| SCHEMBL29420327 | 0.88 | KMT2A (0.56) | KMT2AMEN1KDM4EALDH1A1CYP3A4 | |
| SCHEMBL29420326 | 0.88 | KMT2A (0.56) | KMT2AMEN1KDM4EALDH1A1CYP3A4 | |
| SCHEMBL354177 | 0.88 | KMT2A (0.56) | KMT2AMEN1KDM4EALDH1A1CYP3A4 | |
| SCHEMBL24362699 | 0.87 | HTR2A (0.49) | KMT2AMEN1KDM4EHSD17B1CYP3A4 | |
| SCHEMBL24362549 | 0.87 | HSD17B1 (0.47) | KMT2AMEN1KDM4EALDH1A1HSD17B1 | |
| SCHEMBL25369104 | 0.86 | HSD17B1 (0.46) | KMT2AMEN1KDM4EALDH1A1HSD17B1 | |
| SCHEMBL24362546 | 0.86 | MAPK10 (0.46) | KMT2AMEN1HSD17B1MAPTMAOA | |
| SCHEMBL9620643 | 0.86 | ACHE (0.54) | HSD17B1ACHEMAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0284359-B1 | 1,4-DISUBSTITUTED PIPERAZINE COMPOUNDS, THEIR PRODUCTION AND USE | Takeda Chemical Industries, Ltd. (JP) | 1992-01-08 | — | — | EP | disclosed |
| US-4880809-A | HYPOTENSIVE AGENTS, AMIDE DERIVATIVES | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1989-11-14 | — | — | US | disclosed |