Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 known ✓ | P08172 | 1/20 | 0.44 |
| ▸ | CHRM1 known ✓ | P11229 | 1/20 | 0.44 |
| ▸ | ACHE known ✓ | P22303 | 1/20 | 0.44 |
| ▸ | SLC6A2 known ✓ | P23975 | 1/20 | 0.44 |
| ▸ | SLC6A3 known ✓ | Q01959 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | CASP2 | P42575 | 1/20 | 0.47 |
| ▸ | HSPD1 | P10809 | 1/20 | 0.46 |
| ▸ | RAD52 | P43351 | 1/20 | 0.46 |
| ▸ | HSPE1 | P61604 | 1/20 | 0.46 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.44 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.44 |
| ▸ | ESR1 | P03372 | 1/20 | 0.44 |
| ▸ | PGR | P06401 | 1/20 | 0.44 |
| ▸ | HTR1A | P08908 | 1/20 | 0.44 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL11534436 | 0.98 | MEN1 (0.50) | MEN1KMT2ASMN1; SMN2MAPTMAPK1 | |
| Hydrochloric Acid SCHEMBL960532 | 0.98 | MEN1 (0.50) | MEN1KMT2ASMN1; SMN2MAPTMAPK1 | |
| Hydrochloric Acid SCHEMBL25413444 | 0.98 | MEN1 (0.50) | MEN1KMT2ASMN1; SMN2MAPTMAPK1 | |
| Hydrochloric Acid SCHEMBL25415755 | 0.98 | MEN1 (0.50) | MEN1KMT2ASMN1; SMN2MAPTMAPK1 | |
| Hydrochloric Acid SCHEMBL22026956 | 0.98 | MEN1 (0.50) | MEN1KMT2ASMN1; SMN2MAPTMAPK1 | |
| Hydrochloric Acid SCHEMBL25415803 | 0.98 | MEN1 (0.50) | MEN1KMT2ASMN1; SMN2MAPTMAPK1 | |
| SCHEMBL899200 | 0.98 | ABCB11 (0.45) | MEN1KMT2ASMN1; SMN2HSP90AA1ABCB11 | |
| SCHEMBL899147 | 0.96 | ABCB11 (0.48) | MEN1KMT2ASMN1; SMN2HSP90AA1ABCB11 | |
| SCHEMBL5288768 | 0.96 | ABCB11 (0.48) | MEN1KMT2ASMN1; SMN2HSP90AA1ABCB11 | |
| SCHEMBL409128 | 0.96 | ABCB11 (0.48) | MEN1KMT2ASMN1; SMN2HSP90AA1ABCB11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9267214-B2 | Aluminum recovery process | BOARD OF TRUSTEES OF THE UNIVERSITY OF ALABAMA (US) | 2016-02-23 | — | — | US | claimed |
| US-20110000782-A1 | ALUMINUM RECOVERY PROCESS | THE UNIVERSITY OF ALABAMA (US) | 2011-01-06 | — | — | US | claimed |
| US-9267214-B2 | Aluminum recovery process | BOARD OF TRUSTEES OF THE UNIVERSITY OF ALABAMA (US) | 2016-02-23 | — | — | US | disclosed |
| US-20110000782-A1 | ALUMINUM RECOVERY PROCESS | THE UNIVERSITY OF ALABAMA (US) | 2011-01-06 | — | — | US | disclosed |