Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | LTB4R | Q15722 | 2/20 | 0.40 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | CALM1 | P0DP23 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | HRH1 | P35367 | 1/20 | 0.39 |
| ▸ | BCL2 | P10415 | 1/20 | 0.38 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.38 |
| ▸ | GCGR | P47871 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9435590 | 0.79 | P2RX3 (0.44) | LTB4RKDM4EALDH1A1HPGDCALM1 | |
| SCHEMBL7623426 | 0.77 | MAOB (0.49) | TP53HRH4KDM4EALDH1A1HPGD | |
| SCHEMBL21306242 | 0.75 | CALM1 (0.61) | LTB4RHRH4KDM4EALDH1A1HPGD | |
| SCHEMBL20543627 | 0.73 | SMN1; SMN2 (0.41) | ALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL9621246 | 0.72 | GLA (0.43) | KDM4EALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL9621285 | 0.71 | HTR2C (0.41) | LTB4RKDM4EALDH1A1CALM1BCL2 | |
| SCHEMBL9744009 | 0.71 | SMN1; SMN2 (0.44) | TP53KDM4EALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL4402741 | 0.71 | ESR1 (0.59) | KDM4EALDH1A1 | |
| SCHEMBL12843879 | 0.71 | TP53 (0.46) | TP53LTB4RKDM4ECALM1 | |
| SCHEMBL20087797 | 0.70 | TP53 (0.41) | TP53LTB4RHRH4KDM4ECALM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0252670-B1 | 2-SUBSTITUTED ALKOXY-3-SUBSTITUTED-PYRAZINES | TOYO JOZO KABUSHIKI KAISHA (JP) | 1992-01-15 | — | — | EP | disclosed |
| US-5001237-A | 2-substituted alkoxy-3-substituted-pyrazines | TOYO JOZO KABUSHIKI KAISHA (JP) | 1991-03-19 | — | — | US | disclosed |
| EP-0242957-B1 | 1-SUBSTITUTED ALKYL-1, 2-DIHYDRO-2-PYRAZINONE DERIVATIVES | TOYO JOZO KABUSHIKI KAISHA (JP) | 1990-09-12 | — | — | EP | disclosed |
| US-4894453-A | ANTICOAGULANTS, CARDIOVASCULAR DISORDERS | TOYO JOZO KABUSHIKI KAISHA (JP) | 1990-01-16 | — | — | US | disclosed |
| US-4877875-A | ANTIAGGLOMERANTS, VASODILATORS | TOYO JOZO KABUSHIKI KAISHA (JP) | 1989-10-31 | — | — | US | disclosed |
| US-4877877-A | PLATELET AGGREGATION INHIBITORS, VASODILATORS AND ANTI-LIPOPEROXIDE GENERATORS | TOYO JOZO KABUSHIKI KAISHA (JP) | 1989-10-31 | — | — | US | disclosed |
| US-4870176-A | ANTI-LIPOPEROXIDE, VASODILATION, ANTICOAGULANTS | TOYO JOZO KABUSHIKI KAISHA (JP) | 1989-09-26 | — | — | US | disclosed |
| US-4837319-A | VASODILATORS, ANTICOAGULANTS | TOYO JOZO KABUSHIKI KAISHA (JP) | 1989-06-06 | — | — | US | disclosed |
| EP-0252670-A2 | 2-Substituted alkoxy-3-substituted-pyrazines | TOYO JOZO KABUSHIKI KAISHA (JP) | 1988-01-13 | — | — | EP | disclosed |
| EP-0242957-A1 | 1-Substituted Alkyl-1, 2-Dihydro-2-Pyrazinone derivatives | TOYO JOZO KABUSHIKI KAISHA (JP) | 1987-10-28 | — | — | EP | disclosed |