SCHEMBL9621839

SCHEMBL9621839

O=C1CCCN1C(=O)CC(=O)N1CCCC1=O

nearest known ligand 0.76

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LMNA P02545 2/20 0.76
TDP1 Q9NUW8 3/20 0.45
POLB P06746 1/20 0.45
TSHR P16473 1/20 0.44
CASP6 P55212 1/20 0.43
L3MBTL1 Q9Y468 1/20 0.43
KMT2A Q03164 4/20 0.42
KDM4E B2RXH2 1/20 0.42
MEN1 O00255 1/20 0.42
CYP1A2 P05177 1/20 0.42
CYP2D6 P10635 1/20 0.42
MAPT P10636 1/20 0.42
THRB P10828 1/20 0.42
CYP2C9 P11712 1/20 0.42
CYP2C19 P33261 1/20 0.42
RECQL P46063 1/20 0.42
BLM P54132 1/20 0.42
RAB9A P51151 1/20 0.40
BRD4 O60885 1/20 0.39
BRD2 P25440 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28007670 0.88 LMNA (0.66) LMNATDP1POLBTSHRCASP6
SCHEMBL14336999 0.88 LMNA (0.66) LMNATDP1POLBTSHRCASP6
SCHEMBL5182541 0.86 LMNA (1.00) LMNATDP1POLBTSHRCASP6
SCHEMBL11251350 0.85 LMNA (0.61) LMNATDP1POLBTSHRCASP6
SCHEMBL20107836 0.84 LMNA (0.73) LMNATDP1POLBTSHRCASP6
SCHEMBL5147430 0.83 LMNA (0.70) LMNATDP1POLBTSHRCASP6
SCHEMBL5180649 0.83 LMNA (0.84) LMNATDP1POLBTSHRCASP6
SCHEMBL952927 0.83 LMNA (0.70) LMNATDP1POLBTSHRCASP6
SCHEMBL9333110 0.83 LMNA (0.70) LMNATDP1POLBTSHRCASP6
SCHEMBL15886469 0.83 LMNA (0.70) LMNATDP1POLBTSHRCASP6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0202419-B1 LACTAM-BLOCK COPOLYMERS AlliedSignal Inc. (US) 1992-02-12 EP disclosed
US-4843127-A POLYCARBOXYLIC ACID WITH POLYETHER OR POLYSULFIDE ALLIED-SIGNAL INC. (US) 1989-06-27 US disclosed
EP-0202419-A2 Lactam-block copolymers AlliedSignal Inc. (US) 1986-11-26 EP disclosed
US-4599398-A GRIGNARD CATALYST, DUAL INITIATOR PPG INDUSTRIES, INC. (US) 1986-07-08 US disclosed
US-4501861-A BLEND OF POLYCAPROLACTAM AND BLOCK POLYMER MONSANTO COMPANY (US) 1985-02-26 US disclosed
US-4501821-A HETEROCYCLIC IMIDES OR ACYLUREAS AND POLYMERS HAVING THESE END GROUPS; MOLDING POLYCAPROLACTAM PPG INDUSTRIES, INC. (US) 1985-02-26 US disclosed
US-4346200-A Thermoplastic polyamide compositions MONSANTO COMPANY (US) 1982-08-24 US disclosed
US-4223112-A FIBERS, FOAMS, MOLDING MATERIALS MONSANTO COMPANY (US) 1980-09-16 US disclosed
US-RE30371-E POLYESTERAMIDES FROM ACYLLACTAMS AND ALCOHOLS, METAL ANIONIC CATALYSTS MONSANTO COMPANY (US) 1980-08-12 US disclosed
US-4034015-A LACTAM-POLYOL-POLYACYL LACTAM OR LACTAM-POLYOL-ACYL POLYLACTAM, BLOCK POLYMERS MONSANTO COMPANY (US) 1977-07-05 US disclosed
US-4031164-A LACTAM, POLYOL, POLYACYL LACTAM, CATALYST MONSANTO COMPANY (US) 1977-06-21 US disclosed
US-3965075-A POLYAMIDEESTERS FROM N-ACYLLACTAMS AND ALCOHOLS; TERT-AMINE OR ORGANOMETALLIC CATALYST MONSANTO COMPANY 1976-06-22 US disclosed