Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.55 |
| ▸ | MAPT | P10636 | 3/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.55 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.55 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.55 |
| ▸ | GFER | P55789 | 1/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.55 |
| ▸ | POLB | P06746 | 3/20 | 0.52 |
| ▸ | STAT3 | P40763 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.50 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | SIK1 | P57059 | 1/20 | 0.48 |
| ▸ | SIK2 | Q9H0K1 | 1/20 | 0.48 |
| ▸ | SIK3 | Q9Y2K2 | 1/20 | 0.48 |
| ▸ | PARP15 | Q460N3 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL423775 | 0.85 | PARP15 (0.58) | ALDH1A1SMN1; SMN2MAPTCYP1A2CYP2C9 | |
| SCHEMBL1221627 | 0.85 | POLB (0.63) | ALDH1A1SMN1; SMN2MAPTCYP1A2CYP2C9 | |
| SCHEMBL30362007 | 0.85 | POLB (0.63) | ALDH1A1SMN1; SMN2MAPTCYP1A2CYP2C9 | |
| SCHEMBL1821903 | 0.83 | PTGDR2 (0.63) | ALDH1A1SMN1; SMN2MAPTCYP1A2CYP2C9 | |
| Hydrochloric Acid SCHEMBL27134662 | 0.83 | POLB (0.61) | ALDH1A1SMN1; SMN2MAPTCYP1A2CYP2C9 | |
| SCHEMBL3917916 | 0.81 | MAPT (0.48) | ALDH1A1SMN1; SMN2MAPTCYP1A2CYP2C9 | |
| SCHEMBL392403 | 0.81 | ALDH1A1 (0.59) | ALDH1A1SMN1; SMN2MAPTCYP1A2CYP2C9 | |
| SCHEMBL477809 | 0.81 | MAPT (0.55) | ALDH1A1SMN1; SMN2MAPTCYP1A2CYP2C9 | |
| SCHEMBL30362156 | 0.81 | MAPT (0.55) | ALDH1A1SMN1; SMN2MAPTCYP1A2CYP2C9 | |
| SCHEMBL30361998 | 0.81 | ALDH1A1 (0.59) | ALDH1A1SMN1; SMN2MAPTCYP1A2CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 25 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10301305-B2 | Heteroaromatic derivatives and their use as pharmaceuticals | MUTABILIS (FR) | 2019-05-28 | — | — | US | disclosed |
| US-20180298026-A1 | Pyrazolo[1,5a]Pyrimidine Derivatives as IRAK4 Modulators | HOFFMANN-LA ROCHE INC. | 2018-10-18 | — | — | US | disclosed |
| US-10023589-B2 | Pyrazolo[1,5a]pyrimidine derivatives as IRAK4 modulators | HOFFMANN-LA ROCHE INC. (US) | 2018-07-17 | — | — | US | disclosed |
| EP-3110803-B1 | HETEROAROMATIC DERIVATIVES AND THEIR USE AS PHARMACEUTICALS | MUTABILIS (FR) | 2018-07-11 | — | — | EP | disclosed |
| EP-3252054-A1 | PYRAZOLO[1,5A]PYRIMIDINE DERIVATIVES AS IRAK4 MODULATORS | F. Hoffmann-La Roche AG (CH) | 2017-12-06 | — | — | EP | disclosed |
| EP-2593457-B1 | PYRAZOLO[1,5A]PYRIMIDINE AND THIENO[3,2B]PYRIMIDINE DERIVATIVES AS IRAK4 MODULATORS | HOFFMANN LA ROCHE (CH) | 2017-08-23 | — | — | EP | disclosed |
| US-20170015661-A1 | HETEROAROMATIC DERIVATIVES AND THEIR USE AS PHARMACEUTICALS | MUTABILIS (FR) | 2017-01-19 | — | — | US | disclosed |
| EP-3110803-A1 | HETEROAROMATIC DERIVATIVES AND THEIR USE AS PHARMACEUTICALS | Mutabilis (FR) | 2017-01-04 | — | — | EP | disclosed |
| US-20160207936-A1 | PYRAZOLO[1,5a]PYRIMIDINE DERIVATIVES AS IRAK4 MODULATORS | HOFFMANN-LA ROCHE INC. | 2016-07-21 | — | — | US | disclosed |
| US-9255110-B2 | Pyrazolo[1,5a]pyrimidine derivatives as IRAK4 modulators | ROCHE PALO ALTO LLC (US) | 2016-02-09 | — | — | US | disclosed |
| WO-2011022393-A2 | PHOSPHATIDYLCHOLINE TRANSFER PROTEIN INHIBITORS | THE BRIGHAM AND WOMEN'S HOSPITAL, INC. (US) | 2011-02-24 | — | — | WO | disclosed |
| EP-0199973-B1 | PROCESS FOR THE PRODUCTION ON THE FIBRE OF WATER INSOLUBLE AZO DYES | HOECHST AKTIENGESELLSCHAFT (DE) | 1992-04-15 | — | — | EP | disclosed |
| EP-0300390-B1 | TRIFLUOROMETHYL-ALKOXY-ANILIN, PROCESS FOR THEIR PREPARATION AND THEIR USE IN THE ICE-COLOUR TECHNIQUE | HOECHST AKTIENGESELLSCHAFT (DE) | 1990-08-29 | — | — | EP | disclosed |
| EP-0362725-A1 | Process for producing water insoluble azo dyes on the fibre according to the ice-colour technique | HOECHST AKTIENGESELLSCHAFT (DE) | 1990-04-11 | — | — | EP | disclosed |
| EP-0362729-A1 | Process for producing water insoluble azo dyes on the fibre | HOECHST AKTIENGESELLSCHAFT (DE) | 1990-04-11 | — | — | EP | disclosed |
| US-4906250-A | Process for the preparation of water-insoluble azo dyes on the fiber: impregnating with coupling component and treating with diazonium salt of 4-chloro-2,5-dialkoxy aniline | HOECHST AKTIENGESELLSCHAFT, A CORP. OF THE FEDERAL REPUBLIC OF GERMANY (DE) | 1990-03-06 | — | — | US | disclosed |
| EP-0312003-A2 | Process of manufacturing water insolubles azodyes on the fibre | HOECHST AKTIENGESELLSCHAFT (DE) | 1989-04-19 | — | — | EP | disclosed |
| EP-0300390-A1 | Trifluoromethyl-alkoxy-anilin, process for their preparation and their use in the ice-colour technique | HOECHST AKTIENGESELLSCHAFT (DE) | 1989-01-25 | — | — | EP | disclosed |
| US-4696675-A | Process for preparing water-insoluble blue azo dyes on the fiber: hydroxynaphthoic amide and diazotized di-alkoxy-benzidine | HOECHST AKTIENGESELLSCHAFT (DE) | 1987-09-29 | — | — | US | disclosed |
| EP-0199973-A2 | Process for the production on the fibre of water insoluble azo dyes | HOECHST AKTIENGESELLSCHAFT (DE) | 1986-11-05 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160207936-A1 | PYRAZOLO[1,5a]PYRIMIDINE DERIVATIVES AS IRAK4 MODULATORS | IRAK4, IRAK1, IRAK2 | ALDH1A1 2519/4885SMN1; SMN2 1363/4885MAPT 1941/4885 |
| US-10023589-B2 | Pyrazolo[1,5a]pyrimidine derivatives as IRAK4 modulators | IRAK4, IRAK1, IRAK2 | ALDH1A1 2519/4885SMN1; SMN2 1363/4885MAPT 1941/4885 |
| US-20170015661-A1 | HETEROAROMATIC DERIVATIVES AND THEIR USE AS PHARMACEUTICALS | MSR1, IFNAR1, NOD2 | ALDH1A1 2744/4885SMN1; SMN2 4422/4885MAPT 4761/4885 |
| US-10301305-B2 | Heteroaromatic derivatives and their use as pharmaceuticals | MSR1, IFNAR1, NOD2 | ALDH1A1 2744/4885SMN1; SMN2 4422/4885MAPT 4761/4885 |
| US-20180298026-A1 | Pyrazolo[1,5a]Pyrimidine Derivatives as IRAK4 Modulators | IRAK4, IRAK1, IRAK2 | ALDH1A1 2519/4885SMN1; SMN2 1363/4885MAPT 1941/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.