Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DBH | P09172 | 3/20 | 0.51 |
| ▸ | CACNA1H | O95180 | 4/20 | 0.35 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.35 |
| ▸ | CACNA1I | Q9P0X4 | 1/20 | 0.35 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9621820 | 0.82 | DBH (0.54) | DBHKMT2ACYP19A1TDP1ALDH1A1 | |
| SCHEMBL10573932 | 0.80 | DBH (0.48) | DBH | |
| SCHEMBL10578492 | 0.80 | KCNH2 (0.32) | DBHP2RX7KCNH2 | |
| Hydrochloric Acid SCHEMBL10573573 | 0.79 | KCNH2 (0.32) | DBHP2RX7KCNH2 | |
| SCHEMBL9400818 | 0.78 | DBH (0.44) | DBHKCNH2 | |
| SCHEMBL10400364 | 0.77 | ALDH1A1 (0.42) | DBHKMT2ACYP1A2CYP2D6CYP2C19 | |
| SCHEMBL10718339 | 0.77 | DBH (0.48) | DBHCACNA1HCACNA1GCACNA1IP2RX7 | |
| SCHEMBL10577272 | 0.74 | KCNH2 (0.34) | ALDH1A1KCNH2 | |
| SCHEMBL10618795 | 0.74 | — | — | |
| SCHEMBL10583377 | 0.74 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0260814-B1 | DOPAMINE-BETA-HYDROXYLASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 1992-02-05 | — | — | EP | claimed |
| EP-0288488-A4 | DOPAMINE- -HYDROXYLASE INHIBITORS | — | 1990-09-12 | — | — | EP | claimed |
| EP-0288488-A1 | DOPAMINE- -HYDROXYLASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 1988-11-02 | — | — | EP | claimed |
| EP-0260814-A1 | Dopamine-Beta-hydroxylase inhibitors | SMITHKLINE BEECHAM CORPORATION (US) | 1988-03-23 | — | — | EP | claimed |
| WO-1988001267-A1 | DOPAMINE-ss-HYDROXYLASE INHIBITORS | SMITHKLINE BECKMAN CORPORATION (US) | 1988-02-25 | — | — | WO | claimed |
| EP-0260814-B1 | DOPAMINE-BETA-HYDROXYLASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 1992-02-05 | — | — | EP | disclosed |
| US-4992459-A | Hypotensive agents, antiulcer agents | SMITHKLINE BEECHAM CORPORATION (US) | 1991-02-12 | — | — | US | disclosed |
| EP-0288488-A4 | DOPAMINE- -HYDROXYLASE INHIBITORS | — | 1990-09-12 | — | — | EP | disclosed |
| US-4935438-A | Dopamine-β-hydroxylase inhibitors | SMITHKLINE BECKMAN CORPORATION (US) | 1990-06-19 | — | — | US | disclosed |
| WO-1989006128-A1 | 2-CARBOXYALKYLTHIOIMIDAZOLES AND ESTERS THEREOF AS DOPAMINE-beta-HYDROXYLASE INHIBITORS | SMITHKLINE BECKMAN CORPORATION (US) | 1989-07-13 | — | — | WO | disclosed |
| EP-0323146-A2 | Dopamine-beta-hydroxylase inhibitors | SMITHKLINE BEECHAM CORPORATION (US) | 1989-07-05 | — | — | EP | disclosed |
| EP-0288488-A1 | DOPAMINE- -HYDROXYLASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 1988-11-02 | — | — | EP | disclosed |
| EP-0260814-A1 | Dopamine-Beta-hydroxylase inhibitors | SMITHKLINE BEECHAM CORPORATION (US) | 1988-03-23 | — | — | EP | disclosed |
| WO-1988001267-A1 | DOPAMINE-ss-HYDROXYLASE INHIBITORS | SMITHKLINE BECKMAN CORPORATION (US) | 1988-02-25 | — | — | WO | disclosed |