Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DBH | P09172 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.43 |
| ▸ | GRK2 | P25098 | 1/20 | 0.43 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | CSF1R | P07333 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10337152 | 0.90 | ALDH1A1 (0.49) | DBHALDH1A1HTTCYP17A1GRK2 | |
| SCHEMBL9621670 | 0.84 | ALDH1A1 (0.55) | DBHALDH1A1HTTMAPK1SMN1; SMN2 | |
| SCHEMBL9837829 | 0.83 | ALDH1A1 (0.42) | DBHALDH1A1HTTTDP1KMT2A | |
| SCHEMBL10400364 | 0.83 | ALDH1A1 (0.42) | DBHALDH1A1HTTCYP17A1LMNA | |
| SCHEMBL9622057 | 0.82 | DBH (0.51) | DBHALDH1A1HTTCYP19A1TDP1 | |
| SCHEMBL10594119 | 0.79 | DBH (0.51) | DBHCYP17A1CYP19A1RAB9A | |
| SCHEMBL9838126 | 0.79 | ALDH1A1 (0.71) | ALDH1A1HTTSMN1; SMN2LMNAKMT2A | |
| SCHEMBL9622071 | 0.77 | CYP1A2 (0.51) | ALDH1A1SMN1; SMN2LMNAL3MBTL1KMT2A | |
| SCHEMBL10593221 | 0.75 | LPO (0.58) | ALDH1A1ROCK2LMNAKMT2A | |
| SCHEMBL9836342 | 0.75 | RAB9A (0.48) | DBHCYP19A1SMN1; SMN2LMNAL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0260814-B1 | DOPAMINE-BETA-HYDROXYLASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 1992-02-05 | — | — | EP | claimed |
| US-4992459-A | Hypotensive agents, antiulcer agents | SMITHKLINE BEECHAM CORPORATION (US) | 1991-02-12 | — | — | US | claimed |
| EP-0288488-A4 | DOPAMINE- -HYDROXYLASE INHIBITORS | — | 1990-09-12 | — | — | EP | claimed |
| EP-0288488-A1 | DOPAMINE- -HYDROXYLASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 1988-11-02 | — | — | EP | claimed |
| EP-0260814-A1 | Dopamine-Beta-hydroxylase inhibitors | SMITHKLINE BEECHAM CORPORATION (US) | 1988-03-23 | — | — | EP | claimed |
| WO-1988001267-A1 | DOPAMINE-ss-HYDROXYLASE INHIBITORS | SMITHKLINE BECKMAN CORPORATION (US) | 1988-02-25 | — | — | WO | claimed |
| CN-87105734-A | The dopamine-inhibitor | — | 1988-02-24 | — | — | CN | claimed |
| EP-0260814-B1 | DOPAMINE-BETA-HYDROXYLASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 1992-02-05 | — | — | EP | disclosed |
| US-4992459-A | Hypotensive agents, antiulcer agents | SMITHKLINE BEECHAM CORPORATION (US) | 1991-02-12 | — | — | US | disclosed |
| EP-0288488-A4 | DOPAMINE- -HYDROXYLASE INHIBITORS | — | 1990-09-12 | — | — | EP | disclosed |
| EP-0288488-A1 | DOPAMINE- -HYDROXYLASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 1988-11-02 | — | — | EP | disclosed |
| EP-0260814-A1 | Dopamine-Beta-hydroxylase inhibitors | SMITHKLINE BEECHAM CORPORATION (US) | 1988-03-23 | — | — | EP | disclosed |
| WO-1988001267-A1 | DOPAMINE-ss-HYDROXYLASE INHIBITORS | SMITHKLINE BECKMAN CORPORATION (US) | 1988-02-25 | — | — | WO | disclosed |