SCHEMBL9622274

SCHEMBL9622274

Oc1ccc(C=Cc2ccc(O)c(Cl)c2)cc1Cl

nearest known ligand 0.61

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LCK P06239 4/20 0.61
BACE1 P56817 1/20 0.58
HSD17B10 Q99714 2/20 0.54
TSHR P16473 1/20 0.54
NQO2 P16083 3/20 0.52
ALOX12 P18054 2/20 0.50
MEN1 O00255 2/20 0.50
KMT2A Q03164 2/20 0.50
RGS12 O14924 1/20 0.50
TP53 P04637 1/20 0.50
CYP1A2 P05177 1/20 0.50
CYP3A4 P08684 1/20 0.50
CYP2C9 P11712 1/20 0.50
PKM P14618 1/20 0.50
ALOX15 P16050 1/20 0.50
CASP1 P29466 1/20 0.50
THPO P40225 1/20 0.50
GNAI1 P63096 1/20 0.50
HIF1A Q16665 1/20 0.50
KDM4E B2RXH2 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9622273 1.00 LCK (0.61) LCKBACE1HSD17B10TSHRNQO2
SCHEMBL11286011 0.89 PTPN1 (0.58) LCKBACE1NQO2PTPN2PTPN1
SCHEMBL11286008 0.89 PTPN1 (0.58) LCKBACE1NQO2PTPN2PTPN1
SCHEMBL4257044 0.83 BACE1 (0.49) LCKBACE1NQO2ALDH1A1LMNA
SCHEMBL5692808 0.83 BACE1 (0.56) BACE1KDM4EALDH1A1TTRPOLB
SCHEMBL4257041 0.83 BACE1 (0.49) LCKBACE1NQO2ALDH1A1LMNA
SCHEMBL5692806 0.83 BACE1 (0.56) BACE1KDM4EALDH1A1TTRPOLB
SCHEMBL11001027 0.83 TSHR (0.52) LCKBACE1HSD17B10TSHRMEN1
SCHEMBL6022866 0.82 KDM4E (0.70) BACE1HSD17B10TSHRMEN1KMT2A
SCHEMBL6022871 0.82 KDM4E (0.70) BACE1HSD17B10TSHRMEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5128429-A Low temperature block polymerization without randomization RAYCHEM LIMITED (GB) 1992-07-07 US disclosed
EP-0154506-B1 PREPARATION OF ORGANIC POLYMERS RAYCHEM LIMITED (GB) 1992-02-05 EP disclosed
US-4999411-A Polythioethers, polythiocarbonates, polythioamides, polythioimides RAYCHEM LIMITED (GB) 1991-03-12 US disclosed
US-4960835-A ENGINEERING THERMOPLASTICS RAYCHEM LIMITED (GB) 1990-10-02 US disclosed
US-4845179-A CONDENSATION POLYMERIZATION RAYCHEM LIMITED (GB) 1989-07-04 US disclosed
EP-0154506-A2 Preparation of organic polymers RAYCHEM LIMITED (GB) 1985-09-11 EP disclosed