Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITK | Q08881 | 2/20 | 0.44 |
| ▸ | NNMT | P40261 | 3/20 | 0.44 |
| ▸ | GSK3B | P49841 | 1/20 | 0.44 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.43 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.42 |
| ▸ | SYK | P43405 | 5/20 | 0.42 |
| ▸ | LCK | P06239 | 3/20 | 0.41 |
| ▸ | MAPK8 | P45983 | 3/20 | 0.41 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.41 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.41 |
| ▸ | KDR | P35968 | 1/20 | 0.41 |
| ▸ | EGFR | P00533 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10827865 | 0.85 | POLB (0.47) | GSK3BLRRK2LCKMAPK14KDR | |
| SCHEMBL15946663 | 0.84 | LCK (0.46) | LRRK2LCKMAPK14KDR | |
| SCHEMBL14590441 | 0.79 | RAB9A (0.48) | — | |
| SCHEMBL23775486 | 0.78 | NNMT (0.51) | NNMTSYK | |
| SCHEMBL762022 | 0.78 | SYK (0.52) | NNMTLRRK2SYKMAPK8MAPK9 | |
| SCHEMBL3192298 | 0.78 | NNMT (0.47) | NNMTGSK3BSYKMAPK8 | |
| SCHEMBL30962568 | 0.77 | NNMT (0.46) | NNMTGSK3BLRRK2SYK | |
| SCHEMBL30962899 | 0.76 | JAK3 (0.58) | GSK3BSYKKDR | |
| SCHEMBL25224808 | 0.74 | NNMT (0.44) | NNMTGSK3B | |
| SCHEMBL5765616 | 0.74 | POLB (0.49) | NNMTLRRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5137895-A | Antiemetic, anxiolytic, gastric emptying and serotonin modulating activity | A. H. ROBINS COMPANY, INCORPORATED (US) | 1992-08-11 | — | — | US | disclosed |