Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 11/20 | 0.57 |
| ▸ | LMNA | P02545 | 2/20 | 0.57 |
| ▸ | NR3C1 | P04150 | 4/20 | 0.55 |
| ▸ | NR3C2 | P08235 | 4/20 | 0.55 |
| ▸ | PGR | P06401 | 3/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.55 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.55 |
| ▸ | SERPINA6 | P08185 | 2/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.55 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.55 |
| ▸ | MAPT | P10636 | 2/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.55 |
| ▸ | SHBG | P04278 | 1/20 | 0.55 |
| ▸ | AR | P10275 | 1/20 | 0.53 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.53 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9623247 | 0.87 | SHBG (0.58) | HIF1ALMNANR3C1NR3C2PGR | |
| SCHEMBL9623681 | 0.86 | CYP3A4 (0.59) | HIF1ALMNANR3C1NR3C2PGR | |
| SCHEMBL9623278 | 0.85 | HIF1A (0.41) | HIF1ALMNANR3C1NR3C2PGR | |
| SCHEMBL9623647 | 0.84 | NR3C1 (0.56) | HIF1ALMNANR3C1NR3C2PGR | |
| SCHEMBL18878439 | 0.81 | HIF1A (0.71) | HIF1ALMNANR3C1NR3C2PGR | |
| SCHEMBL15920488 | 0.81 | HIF1A (0.67) | HIF1ALMNANR3C1NR3C2PGR | |
| SCHEMBL15904751 | 0.80 | HIF1A (0.68) | HIF1ALMNANR3C1NR3C2PGR | |
| SCHEMBL14523062 | 0.80 | HIF1A (0.68) | HIF1ALMNANR3C1NR3C2PGR | |
| SCHEMBL21973842 | 0.80 | HIF1A (0.68) | HIF1ALMNANR3C1NR3C2PGR | |
| SCHEMBL15920472 | 0.80 | HIF1A (0.68) | HIF1ALMNANR3C1NR3C2PGR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0268400-B1 | STEROIDAL 17ALPHA-SILYL ETHERS AND PROCESS TO CORTICOIDS AND PROGESTERONES | THE UPJOHN COMPANY (US) | 1992-04-29 | — | — | EP | claimed |
| US-4977255-A | Steroidal 17α-silyl ethers and process to corticoids and progesterones | THE UPJOHN COMPANY (US) | 1990-12-11 | — | — | US | claimed |
| EP-0334875-A1 | STEROIDAL 17$g(a)-SILYL ETHERS AND PROCESS TO CORTICOIDS AND PROGGESTERONES | THE UPJOHN COMPANY (US) | 1989-10-04 | — | — | EP | claimed |
| EP-0268400-A1 | Steroidal 17alpha-silyl ethers and process to corticoids and progesterones | THE UPJOHN COMPANY (US) | 1988-05-25 | — | — | EP | claimed |
| WO-1988003534-A1 | STEROIDAL 17alpha-SILYL ETHERS AND PROCESS TO CORTICOIDS AND PROGGESTERONES | THE UPJOHN COMPANY (US) | 1988-05-19 | — | — | WO | claimed |