SCHEMBL9623738

SCHEMBL9623738

C=CCOC(=O)C(=Cc1ccc(O)cc1)C(=O)O

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 4/20 0.45
KDM4E B2RXH2 3/20 0.45
MEN1 O00255 3/20 0.44
KMT2A Q03164 3/20 0.44
CYP3A4 P08684 2/20 0.42
PTP4A3 O75365 1/20 0.42
PTP4A1 Q93096 1/20 0.42
LMNA P02545 2/20 0.41
MAPT P10636 2/20 0.41
NPSR1 Q6W5P4 2/20 0.41
CYP1A2 P05177 1/20 0.41
CYP2C9 P11712 1/20 0.41
CYP2C19 P33261 1/20 0.41
S1PR4 O95977 1/20 0.41
S1PR1 P21453 1/20 0.41
MAPK1 P28482 1/20 0.41
HPGD P15428 2/20 0.41
CISD1 Q9NZ45 1/20 0.41
SLC16A3 O15427 1/20 0.41
SLC16A1 P53985 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9623864 0.84 FLT3 (0.46) ALDH1A1KDM4EMEN1KMT2ALMNA
SCHEMBL8219793 0.82 MEN1 (0.64) ALDH1A1KDM4EMEN1KMT2ACYP3A4
SCHEMBL3519648 0.81 KMT2A (0.68) ALDH1A1KDM4EMEN1KMT2ALMNA
SCHEMBL9534463 0.78 GAA (0.56) ALDH1A1KDM4EMEN1KMT2APTP4A3
SCHEMBL1704759 0.76 ALDH1A1 (0.65) ALDH1A1KDM4EMEN1KMT2ACYP3A4
SCHEMBL10476860 0.76 KMT2A (0.59) ALDH1A1KDM4EMEN1KMT2ACYP3A4
SCHEMBL10476862 0.76 KMT2A (0.59) ALDH1A1KDM4EMEN1KMT2ACYP3A4
SCHEMBL8220561 0.76 FLT3 (0.49) ALDH1A1KDM4EMEN1KMT2ACYP3A4
SCHEMBL15426941 0.76 KDM4E (0.56) ALDH1A1KDM4ECYP3A4MAPTHPGD
Trans-4,4'-Dihydroxystilbene SCHEMBL7622877 0.74 SNCA (0.51) ALDH1A1KDM4EMEN1KMT2ACYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0350386-B1 UNSATURATED DERIVATIVES OF LIPID SOLUBLE BENZAL MALONATES, AND THEIR USE AS UV ABSORBERS IN THE COSMETIC FIELD L'OREAL (FR) 1992-04-08 EP claimed
EP-0350386-A1 Unsaturated derivatives of lipid soluble benzal malonates, and their use as UV absorbers in the cosmetic field L'OREAL (FR) 1990-01-10 EP claimed
EP-0350386-B1 UNSATURATED DERIVATIVES OF LIPID SOLUBLE BENZAL MALONATES, AND THEIR USE AS UV ABSORBERS IN THE COSMETIC FIELD L'OREAL (FR) 1992-04-08 EP disclosed
EP-0350386-A1 Unsaturated derivatives of lipid soluble benzal malonates, and their use as UV absorbers in the cosmetic field L'OREAL (FR) 1990-01-10 EP disclosed