SCHEMBL9534463

SCHEMBL9534463

C=CCOC(=O)C(=Cc1ccc(OC)c(OC)c1)C(=O)O

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GAA P10253 1/20 0.56
TDP1 Q9NUW8 1/20 0.56
MEN1 O00255 1/20 0.48
POLB P06746 1/20 0.48
KMT2A Q03164 1/20 0.48
ALDH1A1 P00352 3/20 0.48
HTT P42858 2/20 0.48
PKM P14618 1/20 0.48
AKR1C2 P52895 1/20 0.46
GLO1 Q04760 2/20 0.46
IKBKB O14920 2/20 0.46
CHUK O15111 2/20 0.46
IKBKG Q9Y6K9 2/20 0.46
KDM4E B2RXH2 3/20 0.46
HPGD P15428 1/20 0.46
ALOX15 P16050 1/20 0.46
MAPK1 P28482 1/20 0.46
SMN1; SMN2 Q16637 1/20 0.46
HSD17B10 Q99714 1/20 0.46
PTP4A3 O75365 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9624035 0.89 KDM4E (0.48) GAATDP1MEN1POLBKMT2A
SCHEMBL11825001 0.85 ALDH1A1 (0.64) GAATDP1MEN1POLBKMT2A
SCHEMBL11824995 0.85 ALDH1A1 (0.64) GAATDP1MEN1POLBKMT2A
SCHEMBL9623864 0.83 FLT3 (0.46) MEN1KMT2AALDH1A1PKMGLO1
SCHEMBL2225902 0.82 GAA (0.75) GAATDP1MEN1KMT2AALDH1A1
SCHEMBL7813363 0.82 GAA (0.75) GAATDP1MEN1KMT2AALDH1A1
SCHEMBL7813366 0.82 GAA (0.75) GAATDP1MEN1KMT2AALDH1A1
SCHEMBL9170930 0.80 MAPT (0.61) GAATDP1MEN1POLBKMT2A
SCHEMBL5686173 0.79 MAPT (0.59) GAATDP1MEN1POLBKMT2A
SCHEMBL9623738 0.78 ALDH1A1 (0.45) MEN1KMT2AALDH1A1PKMKDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0350386-B1 UNSATURATED DERIVATIVES OF LIPID SOLUBLE BENZAL MALONATES, AND THEIR USE AS UV ABSORBERS IN THE COSMETIC FIELD L'OREAL (FR) 1992-04-08 EP claimed
EP-0350386-A1 Unsaturated derivatives of lipid soluble benzal malonates, and their use as UV absorbers in the cosmetic field L'OREAL (FR) 1990-01-10 EP claimed
EP-0570577-A1 COSMETIC FILTERING OIL CONTAINING A SILICONE FILTER AND A BLEND OF VOLATILE SILICONE AND SILICONE OIL OR SILICONE GUM; COSMETIC FILTERING EMULSION CONTAINING SUCH OIL. OREAL (FR) 1993-11-24 EP disclosed
WO-1993010745-A2 COSMETIC FILTERING OIL CONTAINING A SPECIFIC GROUP ORGANOPOLYSILOXANE L'OREAL (FR) 1993-06-10 WO disclosed
EP-0392882-B1 COSMETIC COMPOSITIONS CONTAINING DIORGANOPOLYSILOXANES WITH A BENZALMALONATE FUNCTION FOR SKIN AND HAIR PROTECTION, AND THEIR USE L'OREAL (FR) 1992-10-28 EP disclosed
EP-0358584-B1 DIORGANOPOLYSILOXANES CONTAINING FUNCTIONAL BENZAL MALONATE GROUPS RHONE-POULENC CHIMIE (FR) 1992-09-16 EP disclosed
EP-0350386-B1 UNSATURATED DERIVATIVES OF LIPID SOLUBLE BENZAL MALONATES, AND THEIR USE AS UV ABSORBERS IN THE COSMETIC FIELD L'OREAL (FR) 1992-04-08 EP disclosed
EP-0392882-A1 Cosmetic compositions containing diorganopolysiloxanes with a benzalmalonate function for skin and hair protection, and their use L'OREAL (FR) 1990-10-17 EP disclosed
EP-0358584-A1 Diorganopolysiloxanes containing functional benzal malonate groups RHONE-POULENC CHIMIE (FR) 1990-03-14 EP disclosed
EP-0350386-A1 Unsaturated derivatives of lipid soluble benzal malonates, and their use as UV absorbers in the cosmetic field L'OREAL (FR) 1990-01-10 EP disclosed