Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GHSR | Q92847 | 2/20 | 0.44 |
| ▸ | S1PR1 | P21453 | 5/20 | 0.42 |
| ▸ | S1PR4 | O95977 | 3/20 | 0.42 |
| ▸ | S1PR5 | Q9H228 | 3/20 | 0.42 |
| ▸ | ADRB3 | P13945 | 3/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.42 |
| ▸ | S1PR3 | Q99500 | 2/20 | 0.41 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.41 |
| ▸ | HTR6 | P50406 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.38 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.37 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9626253 | 0.93 | HTR6 (0.44) | GHSRS1PR1S1PR4S1PR5ADRB3 | |
| SCHEMBL9624807 | 0.86 | KDM4E (0.49) | GHSRS1PR1SIGMAR1S1PR3POLB | |
| Bromide SCHEMBL10531026 | 0.85 | KDM4E (0.48) | GHSRS1PR1SIGMAR1S1PR3POLB | |
| Hydrochloric Acid SCHEMBL10531414 | 0.85 | KDM4E (0.48) | GHSRS1PR1SIGMAR1S1PR3POLB | |
| SCHEMBL9625827 | 0.83 | KDM4E (0.50) | GHSRADRB3POLBATM | |
| SCHEMBL9226318 | 0.83 | CACNA1F (0.50) | ADRB3ADRB2ADRB1 | |
| SCHEMBL10528905 | 0.81 | KDM4E (0.50) | GHSRS1PR1SIGMAR1S1PR3POLB | |
| SCHEMBL9624560 | 0.79 | KDM4E (0.48) | GHSRADRB3POLBATMADRB2 | |
| SCHEMBL9225307 | 0.78 | NR3C1 (0.38) | ADRB3POLBNR3C1 | |
| SCHEMBL10529852 | 0.78 | KDM4E (0.43) | GHSRS1PR1S1PR3POLBATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5155268-A | Antiarrhythmic N-aminoalkylene alkyl and aryl sulfonamides | THE UPJOHN COMPANY (US) | 1992-10-13 | — | — | US | disclosed |
| EP-0178874-B1 | ALKYLSULFONAMIDOPHENYLALKYLAMINES | ELI LILLY AND COMPANY (US) | 1989-04-05 | — | — | EP | disclosed |
| US-4596827-A | Antiarrhythmia agents | ELI LILLY AND COMPANY (US) | 1986-06-24 | — | — | US | disclosed |
| EP-0178874-A1 | Alkylsulfonamidophenylalkylamines | ELI LILLY AND COMPANY (US) | 1986-04-23 | — | — | EP | disclosed |
| US-4569801-A | ANTIARRHYTHMIA AGENTS | ELI LILLY AND COMPANY (US) | 1986-02-11 | — | — | US | disclosed |