Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GNRHR | P30968 | 6/20 | 0.45 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.41 |
| ▸ | DRD2 | P14416 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | LTA4H | P09960 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9624254 | 0.93 | GNRHR (0.46) | GNRHRCYP2D6CYP2C9CYP2C19TDP1 | |
| SCHEMBL9624616 | 0.88 | CYP2D6 (0.44) | GNRHRSIGMAR1CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL9624992 | 0.85 | ABCB1 (0.52) | SIGMAR1TDP1KDM4E | |
| SCHEMBL9625255 | 0.81 | SIGMAR1 (0.45) | SIGMAR1DRD2KDM4E | |
| SCHEMBL9624622 | 0.81 | GNRHR (0.46) | GNRHRCYP2D6CYP2C9CYP2C19TDP1 | |
| SCHEMBL9623814 | 0.79 | SIGMAR1 (0.41) | SIGMAR1DRD2KDM4E | |
| SCHEMBL9623969 | 0.78 | GNRHR (0.47) | GNRHRCYP2D6CYP2C9CYP2C19TDP1 | |
| SCHEMBL9625671 | 0.78 | KDM4E (0.38) | GNRHRSIGMAR1KDM4E | |
| SCHEMBL9624797 | 0.71 | PDE10A (0.43) | DRD2CYP2D6CYP2C9CYP2C19TDP1 | |
| SCHEMBL9624080 | 0.71 | SMN1; SMN2 (0.39) | SIGMAR1KDM4EPOLBTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5116986-A | HETEROAROMATIC AMINE DERIVATIVES | DR. KARL THOMAE GMBH (DE) | 1992-05-26 | — | — | US | disclosed |